BEGIN:VCALENDAR
VERSION:2.0
PRODID:www.eu-parc.eu
BEGIN:VEVENT
UID:6a19ce3353ec5
DTSTART:20260611T140000Z
SEQUENCE:0
TRANSP:OPAQUE
DTEND:20260611T150000Z
SUMMARY:Translating in vitro mechanistic findings to in vivo toxicity outco
mes: A case study of Usnic acid hepatotoxicity
CLASS:PUBLIC
DESCRIPTION:The webinar Translating in vitro mechanistic findings to in viv
o toxicity outcomes: A case study of Usnic acid hepatotoxicity will take p
lace on 11 June 2026 at 16:00 CET. The session will explore how New Approa
ch Methodologies (NAMs)\, quantitative in vitro–to–in vivo extrapolati
on (QIVIVE)\, and physiologically based pharmacokinetic (PBPK) modelling c
an be used to translate mechanistic laboratory findings into meaningful hu
man health risk assessment outcomes. Using usnic acid hepatotoxicity as a
case study\, the webinar will demonstrate how mechanistic evidence can sup
port next-generation safety assessments of botanical constituents.Target a
udienceThis webinar is particularly relevant for toxicologists\, risk asse
ssors\, regulatory scientists\, pharmacokinetic modellers\, NAM developers
\, academic researchers\, and professionals involved in botanical safety e
valuation\, chemical safety assessment\, and regulatory toxicology. The we
binar is open to all interested participants\, although prior registration
is required.
X-ALT-DESC;FMTTYPE=text/html:The webinar
Translating in vitro mechanistic findings to in vivo toxicity outcomes: A
case study of Usnic acid hepatotoxicity will take place on 11 June 20
26 at 16:00 CET. The session will explore how New Approach Methodologies (
NAMs)\, quantitative in vitro–to–in vivo extrapolation (QIVIV
E)\, and physiologically based pharmacokinetic (PBPK) modelling can be use
d to translate mechanistic laboratory findings into meaningful human healt
h risk assessment outcomes. Using usnic acid hepatotoxicity as a case stud
y\, the webinar will demonstrate how mechanistic evidence can support next
-generation safety assessments of botanical constituents.
Ta
rget audience
This webinar is particularly relevant for toxico
logists\, risk assessors\, regulatory scientists\, pharmacokinetic modelle
rs\, NAM developers\, academic researchers\, and professionals involved in
botanical safety evaluation\, chemical safety assessment\, and regulatory
toxicology. The webinar is open to all interested participants\, although
prior registration is required.
DTSTAMP:20260529T173443Z
END:VEVENT
END:VCALENDAR