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Working together on a shared research and innovation program with European and national risk assessment experts and their scientific networks will lead to advances in chemical risk assessment, benefiting science.

Scientific impact
Models, tools, projects, studies, scientific publications
Number and characteristics of scientific publications

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Scientific publications by month
Environmental and dietary determinants of metal exposure in four-year-old children from a cohort located in an industrial area (Asturias, Northern Spain) AI for predicting chemical-effect associations at the chemical universe level — deepFPlearn
July
Cover_exposure Cover_Cardiac PI3K p110α attenuation delays aging and extends lifespan Occupational and residential exposures to organophosphate and pyrethroid pesticides in a rural setting
August
Cover_prioritization of chemicals Wild fish and seafood species in the western Mediterranean Sea with low safe mercury concentrations Cover_The European exposure science strategy 2020–2030
September
Cover_Ecotoxicity characterization of chemicals: Global recommendations and implementation in USEtox Cover_Pharmacophore Modeling Using Machine Learning forScreening the Blood–Brain Barrier Permeation of Xenobiotics Cover_Framework for defining pesticide maximum residue levels in feed: Applications to cattle and sheep Cover_Understanding and addressing the planetary crisis of chemicals and plastics Cover_Application of AOPs to assist regulatory assessment of chemical risks – Case studies, needs and recommendations Cover_Endocrine disrupting chemicals entering European rivers: Occurrence and adverse mixture effects in treated wastewater Cover_Advancing exposure data analytics and repositories as part of the European Exposure Science Strategy 2020–2030 Cover_Establishment of a human cell-based in vitro battery to assess developmental neurotoxicity hazard of chemicals
October
Cover_Generating environmental sampling and testing data for micro- and nanoplastics for use in life cycle impact assessment Cover_Considering degradation kinetics of pesticides in plant uptake models: Proof of concept for potato
November
Cover_Advancing exposure knowledge and its uptake into policy: The European exposure science strategy 2020–2030 (Special Issue) Adverse (geno)toxic effects of bisphenol A and its analogues in hepatic 3D cell model
December
Dynamic metabolic and transcriptional responses of proteasome-inhibited neurons Cover_A walk in the PARC: developing and implementing 21st century chemical risk assessment in Europe Cover_Metabolism-Disrupting Chemicals Affecting the Liver: Screening, Testing, and Molecular Pathway Identification
January
Linking chemicals, genes and morphological perturbations to diseases Cover_Proteome Coverage after Simultaneous Proteo-Metabolome Liquid–Liquid Extraction Cover_The Role of “Physiologically Based Pharmacokinetic Model (PBPK)” New Approach Methodology (NAM) in Pharmaceuticals and Environmental Chemical Risk Assessment
February
Cover_development Cover
March
The exposure of Czech firefighters to perfluoroalkyl substances and polycyclic aromatic hydrocarbons: CELSPAC – FIREexpo case-control human biomonitoring study Rapid extraction and analysis of oxidative stress and DNA damage biomarker 8-hydroxy-2′-deoxyguanosine (8-OHdG) in urine: Application to a study with pregnant women
April
New approach methods to improve human health risk assessment of thyroid hormone system disruption - a PARC project A review on immudolatory effects of BPA analogues
May
G × E interactions as a basis for toxicological uncertainty Non-disclosure of developmental neurotoxicity studies obstructs the safety assessment of pesticides in the European Union AOP-helpFinder 2.0: Integration of an event-event searches module PBTK-TD model of the phagocytosis activity in three-spined stickleback exposed to BPA Mixtures of per- and poly-fluoroalkyl substances (PFAS) reduce the in vitro activation of human T cells and basophils Determination of glyphosate and its derivative, aminomethylphosphonic acid, in human urine by gas chromatography coupled to tandem mass spectrometry and isotope pattern deconvolution Development of new approach methods for the identification and characterization of endocrine metabolic disruptors—a PARC project
June
Development of a rat physiologically based kinetic model (PBK) for three organophosphate flame retardants (TDCIPP, TCIPP, TCEP) Environmental concentrations of tire rubber-derived 6PPD-quinone alter CNS function in zebrafish larvae Firefighters and the liver: Exposure to PFAS and PAHs in relation to liver function and serum lipids (CELSPAC-FIREexpo study) New approach methodologies to facilitate and improve the hazard assessment of non-genotoxic carcinogens—a PARC project REACH Out-Numbered! The Future of REACH and Animal Numbers Innovative tools and methods for toxicity testing within PARC work package 5 on hazard assessment A human iPSC-based in vitro neural network formation assay to investigate neurodevelopmental toxicity of pesticides Deoxynivalenol increases pro-inflammatory cytokine secretion and reduces primary bile acid transport in an inflamed intestinal in vitro co-culture model
July
Development of a physiologically based toxicokinetic model for lead in pregnant women: the role of bone tissue in the maternal and fetal internal exposure A data-derived reference mixture representative of European wastewater treatment plant effluents to complement mixture assessment Adverse outcome pathway-based analysis of liver steatosis in vitro using human liver cell lines Protocol for designing INVITES-IN, a tool for assessing the internal validity of in vitro studies
August
Ciona spp. and ascidians as bioindicator organisms for evaluating effects of endocrine disrupting chemicals: A discussion paper Identification of the bacterial metabolite aerugine as potential trigger of human dopaminergic neurodegeneration Combined western diet and bisphenol A exposure induces an oxidative stress-based paraoxonase 1 response in larval zebrafish
September
Comparison of aggregated exposure to perfluorooctanoic acid (PFOA) from diet and personal care products with concentrations in blood using a PBPK model – Results from the Norwegian biomonitoring study in EuroMix Acceptance criteria for new approach methods in toxicology and human health-relevant life science research - part I A benchmark dataset for machine learning in ecotoxicology
October
Potential for machine learning to address data gaps in human toxicity and ecotoxicity characterization Combined chronic dietary exposure to four nephrotoxic metals exceeds tolerable intake levels in the adult population of 10 European countries Current-use pesticide exposure pathways in Czech adults and children from the CELSPAC-SPECIMEn cohort Ecotoxicological Evaluation of Bisphenol A and Alternatives: A Comprehensive In Silico Modelling Approach Acetylcholinesterase inhibition in rats and humans following acute fenitrothion exposure predicted by physiologically based kinetic modeling-facilitated quantitative in vitroto in vivo extrapolation
November
Mapping chemical footprints of organic micro pollutants in European streams Applicability of food monitoring data for assessing relative exposure contributions of pyrethroids in retrospective human biomonitoring risk estimations
December
A comprehensive battery of flow cytometric immunoassays for the in vitro testing of chemical effects in human blood cells Why adverse outcome pathways need to be FAIR Curated mode-of-action data and effect concentrations for chemicals relevant for the aquatic environment Brain-derived neurotrophic factor (BDNF): an effect biomarker of neurodevelopment in human biomonitoring programs Making food systems more resilient to food safety risks by including artificial intelligence, big data, and internet of things into food safety early warning and emerging risk identification tools Revealing the cascade of pesticide effects from gene to community
January
Intuitive toxicology in the 21st century - Bridging the perspectives of the public and risk assessors in Europe Innovative analytical methodologies for characterizing chemical exposure with a view to next-generation risk assessment Water quality monitoring with the multiplexed assay MitoOxTox for mitochondrial toxicity, oxidative stress response and cytotoxicity in AREc32 cells AOPWIKI-EXPLORER: An interactive graph-based query engine leveraging large language models Exposure to benzotriazoles and benzothiazoles in Czech male population and its associations with biomarkers of liver function, serum lipids and oxidative stress Inconsistencies in the EU regulatory risk assessment of PFAS call for readjustment
March
Estimating the dynamic early life exposure to PFOA and PFOS of the HELIX children: Emerging profiles via prenatal exposure, breastfeeding, and diet Metabolomics in human SGBS cells as new approach method for studying adipogenic effects: Analysis of the effects of DINCH and MINCH on central carbon metabolism Single and mixture effects of bisphenol A and benzophenone-3 on in vitro T helper cell differentiation New approach methods to assess developmental and adult neurotoxicity for regulatory use: a PARC work package 5 project Physiologically based kinetic (PBK) modeling as a new approach methodology (NAM) for predicting systemic levels of gut microbial metabolites The integrated stress response-related expression of CHOP due to mitochondrial toxicity is a warning sign for DILI liability
April
Protocol: Testing the performance of INVITES-IN, A tool for assessing the internal validity of in vitro studies Two-stage machine learning-based approach to predict points of departure for human noncancer and developmental/reproductive effects Regulatory and practical considerations on the implementation of a mixture allocation factor in REACH Exploring BPA alternatives – Environmental levels and toxicity review How wastewater reflects human metabolism - Suspect screening of pharmaceutical metabolites in wastewater influent
May
Machine learning-based prediction of fish acute mortality: implementation, interpretation, and regulatory relevance Effects of metabolic disruption on lipid metabolism and yolk retention in zebrafish embryos Internal flames: Metal(loid) exposure linked to alteration of the lipid profile in Czech male firefighters (CELSPAC-FIREexpo study) Occupational exposure limits for reproductive toxicants – A comparative analysis Automated liquid handling extraction and rapid quantification of underivatized amino acids and tryptophan metabolites from human serum and plasma using dual-column U(H)PLC-MRM-MS and its application to prostate cancer study
June
Predicting the combined effects of multiple stressors and stress adaptation in Gammarus pulex Cross-mapping of terms used in chemical risk assessment with those used in systematic review: research protocol Progress, applications, and challenges in high-throughput effect-directed analysis for toxicity driver identification Investigation of peroxisome proliferator-activated receptor genes as requirements for visual startle response hyperactivity in larval zebrafish exposed to structurally similar per- and polyfluoroalkyl substances (PFAS) Chemical respiratory sensitization
July
High precision blood lead radiogenic isotope signatures in a community exposed to Pb contaminated soils and implications for the current Pb exposure of the European population Pioneering an effect-based early warning system for hazardous chemicals in the environment A systematic workflow for compliancetesting of emerging international classwide restrictions on PFAS A short-term exposure to saxitoxin triggers a multitude of deleterious effects in Daphnia magna at levels deemed safe for human health Associations between urinary phthalate metabolites with BDNF and behavioral function among european children from five HBM4EU aligned studies
August
A conceptual framework for landscape-based environmental risk assessment (ERA) of pesticides
September
Computational tools to facilitate early warning of new emerging risk chemicals Extremely high levels of PBDEs in children’s toys from European markets: causes and implications for the circular economy A critical review to identify data gaps and improve risk assessment of bisphenol A alternatives for human health A preliminary estimate of the environmental burden of disease associated with exposure to pyrethroid insecticides and ADHD in Europe based on human biomonitoring Evaluating the performance of multi-omics integration - a thyroid toxicity case study A comprehensive item bank of internal validity issues of relevance to in vitro toxicology studies
October
Developing quantitative Adverse Outcome Pathways: An ordinary differential equation-based computational framework A comprehensive library of lifetime physiological equations for PBK models Association of environmental pollutants with asthma and allergy, and the mediating role of oxidative stress and immune markers in adolescents
November
A cognitive and sensory approach based on workshops using the zebrafish model promotes the discovery of life sciences in the classroom Zebra_K, a kinematic analysis automated platform for assessing sensitivity, habituation and prepulse inhibition of the acoustic startle response in adult zebrafish
December
Collecting perspectives on project prioritisation process in the EU co-funded multinational partnership for the assessment of risks from chemicals (PARC) through focus group discussion New approach methodologies in human health risk assessment across European regulatory frameworks: Status quo, barriers and drivers for regulatory acceptance and use Daphnids can safeguard the use of alternative bioassays to the acute fish toxicity test: A focus on neurotoxicity Unveiling landscape-level drivers of freshwater biodiversity dynamics Metabolic and molecular characterization, following dietary exposure to DINCH, reveals new implications for its role as a metabolism-disrupting chemical Toward product safety and circularity: Understanding the information structure of global databases on chemicals in products and articles Automated curation of spatial metadata in environmental monitoring data The European Partnership PARC’s role in actively promoting the uptake of new approach methodologies and next-generation risk assessment into regulatory risk assessment practice MLinvitroTox reloaded for high‑throughput hazard‑based prioritization of high‑resolution mass spectrometry data
January
Motor and non-motor effects of acute MPTP in adult zebrafish: insights into Parkinson's disease Modeling zebrafish escape swim reveals maximum neuromuscular power output and efficient body movement adaptation to increased water viscosity
February
Evaluating PFAS-Induced modulation of peripheral blood mononuclear cells (PBMCs) immune response to SARS-CoV-2 spike in COVID-19 Vaccinees
March
Towards prospective identification of respiratory sensitizers Reusing chemical data across disciplines: initiatives and common challenges Spatio-temporal transcriptomic analysis reveals distinct nephrotoxicity, DNA damage, and regeneration response after cisplatin Mapping chemicals across EU's legal frameworks towards a 'one substance, one assessment' approach
April
A tiered next-generation risk assessment framework integrating toxicokinetics and NAM-based toxicodynamics: “proof of concept” case study using pyrethroids
May
Interdisciplinary Assessment of Children's Lead Exposure in Residential Areas Degraded by Mining (Upper Meža Valley, Slovenia)
June
Genetic and epigenetic biomarkers in human biomonitoring: why needed and how can Oxford Nanopore sequencing contribute?
July
MCDA applications in chemical alternatives assessment: a narrative review
August
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