Key messages Assessing chemical exposure at early stage of life is still a challenge. Today, new tools are available that enhance chemical exposure assessment. Efforts are ongoing to refine and clarify the applicability and effectiveness of these approaches. Their value in chemical prioritisation and contribution to early warning systems has...

Overview This project develops and tests an Adverse Outcome Pathway ( AOP) network approach to identify thyroid hormone system disrupting chemicals (THSDCs) in fish. It fills critical gaps in current tools by integrating in silico, in vitro, and in vivo fish test data within a tiered testing strategy aligned with...

Overview This project focuses on improving how to assess the safety of chemical by applying advanced scientific methods that reduce the need for animal testing. It is supporting regulatory decisions by identifying chemicals that may harm human health or the environment. The central focus is using the Adverse Outcome Pathway...

Key messages The battery of genotoxicity in vitro assays is sensitive for the detection of genotoxic carcinogens, but the multifactorial nature of the carcinogenesis process greatly hinders the detection of non-genotoxic carcinogens. The overarching aim of this project is to improve human carcinogenic evaluation in vitro based on reliable and...

Key messages The current regulatory uptake of New Approach Methodologies ( NAMs) and NAM-based approaches for hazard and risk assessment of chemical substances is limited. By conducting case studies addressing specific problem formulations for certain health effects and regulatory contexts we aim to highlight both opportunities and challenges related to...

Overview The European Chemicals Agency ( ECHA) is incorporating international guidelines like the revised OECD Guidance Document 150 into its regulatory processes for evaluating biocides and pesticides for potential endocrine-disrupting effects. However, current testing methods and regulations still fall short when it comes to identifying substances that interfere with the...

Key messages Current biomonitoring methods are limited in assessing the full spectrum of chemical exposures, especially with emerging chemicals in occupational sectors. Innovative screening methods (SS/NTS) and new sampling tools (DBS, SWB) offer a promising alternative to traditional approaches, enabling more comprehensive exposure assessment. The project will demonstrate the proof...

Overview Enhancing the transparency and acceptance of artificial intelligence (AI) and machine learning (ML) techniques in chemical risk assessment is the focus of this initiative. With an increasing reliance on these advanced methods for predicting chemical behaviour and assessing risks, addressing the challenges posed by unclear documentation and limited access...

Key messages This project aims to assist Member State regulatory authorities, EU agencies, scientific committees, expert groups, relevant Commission departments and the industry in adopting harmonised risk assessment methodologies on selected human health effects: Contribute to a harmonised way of using existing and emerging New Approach Methodologies ( NAMs) for...