An in-depth look at the development and validation of QSAR models for chemical risk assessment, covering molecular descriptors, statistical modeling techniques, applicability domains, and the principles guiding regulatory acceptance.

Presents the use of salivary leukocytes as a non-invasive biomatrix for assessing DNA damage and repair in biomonitoring studies using the comet assay, including methodological optimization and validation of both fresh and cryopreserved samples.

An overview of in silico approaches in PARC, highlighting VEGA software and integrated platforms for assessing chemical properties aligned with SSbD principles.

Covers key features and future plans for the QSAR Toolbox, including integration with IUCLID and applications in non-animal hazard assessment.

Webinar on stakeholder use of the OECD QSAR Toolbox, with insights from OECD and ECHA on its role in REACH and as an alternative to animal testing for chemical assessment.

Covers REACH requirements for QSAR-based adaptations, ECHA’s evaluation approach, and typical deficiencies identified in submitted QSAR studies.

Discusses the potential of non-animal models to transform safety assessment and therapeutic development, with insights from pandemic-driven advances in regulatory science.