Presents the use of salivary leukocytes as a non-invasive biomatrix for assessing DNA damage and repair in biomonitoring studies using the comet assay, including methodological optimization and validation of both fresh and cryopreserved samples.

An in-depth look at the development and validation of QSAR models for chemical risk assessment, covering molecular descriptors, statistical modeling techniques, applicability domains, and the principles guiding regulatory acceptance.

Introduces the principles and applications of Non-Targeted Screening (NTS) using LC-HRMS, with emphasis on broader chemical characterisation, harmonised workflows, and methodological developments in the field.

An overview of in silico approaches in PARC, highlighting VEGA software and integrated platforms for assessing chemical properties aligned with SSbD principles.

Covers SSbD policy context, scoping actions, and a case-based walkthrough of the PLANETS Workflow, with full supporting materials and worksheet.

Discover insights into nanomaterials' human and environmental toxicology, as well as of emissions and exposure in all stages of the lifecycle of a nanomaterial. This research supports Safe(r)-and-sustainable-by-design approaches in developing and producing novel materials.

Discover the 2024 Safe and Sustainable by Design (SSbD) Boot Camp, hosted by PARC and AUTH in Thessaloniki. Explore expert presentations, insights into the EU SSbD framework, and discussions on integrating SSbD into research, industry, and innovation.

Discover the 2024 Safe and Sustainable by Design (SSbD) Boot Camp, hosted by PARC and AUTH in Thessaloniki. Explore expert presentations, insights into the EU SSbD framework, and discussions on integrating SSbD into research, industry, and innovation.

Discover the 2024 Safe and Sustainable by Design (SSbD) Boot Camp, hosted by PARC and AUTH in Thessaloniki. Explore expert presentations, insights into the EU SSbD framework, and discussions on integrating SSbD into research, industry, and innovation.

Discover the 2024 Safe and Sustainable by Design (SSbD) Boot Camp, hosted by PARC and AUTH in Thessaloniki. Explore expert presentations, insights into the EU SSbD framework, and discussions on integrating SSbD into research, industry, and innovation.

This webinar explores the exposome framework in toxicology, focusing on multi-stressor interactions, long-term effects, and regulatory implications for environmental health.

Explore the SUNSHINE e-learning focusing on Safe-and-Sustainable-by-Design (SSbD) for advanced nanomaterials. Access recordings and presentations from workshops, webinars, and annual meetings, offering insights into digital tools and sustainability innovations.

Focused on occupational safety, this report explores training needs for workers handling nanomaterials and advanced materials. It includes insights from stakeholder consultations and outlines guidelines for harmonized risk management training across Europe.

Outlines key concepts in toxicological risk assessment, including critical effects, guidance values, toxicokinetics, and uncertainty factors used in public health decision-making.

Presents Canada’s OHARA initiative to operationalize a One Health approach to risk assessment, emphasizing multisectoral coordination, environmental integration, and protocol development.

Discover the 2023 Safe and Sustainable by Design (SSbD) Boot Camp, hosted by the European Commission Joint Research Centre and PARC. This event offers insights into SSbD, the EU framework, expert-led sessions, and networking opportunities within a growing SSbD community.

Discover the 2023 Safe and Sustainable by Design (SSbD) Boot Camp, hosted by the European Commission Joint Research Centre and PARC. This event offers insights into SSbD, the EU framework, expert-led sessions, and networking opportunities within a growing SSbD community.

Join the 2023 Safe and Sustainable by Design (SSbD) Boot Camp, hosted by the European Commission Joint Research Centre and PARC. This event offers insights into SSbD, the EU framework, expert-led sessions, and networking opportunities within a growing SSbD community.

Covers the role of industrial toxicology in regulatory compliance, product stewardship, and risk-based evaluation across sectors including chemicals, pharmaceuticals, and consumer goods.

ECHA’s approach to group substance assessments, upcoming improvements in communication to registrants, and how to respond if your substance is included.

An educational resource offering scientific insights and practical examples on human biomonitoring to support chemical risk assessment and public health decision-making.

Focused on the Safe(r) and Sustainable Innovation Approach (SSIA), this resource explores the integration of safety and sustainability into material design, regulatory anticipation, and collaborative knowledge-sharing frameworks to keep pace with rapid material innovation.

Slide-based resource on OECD test guidelines, supporting science-regulation knowledge transfer, harmonisation, and onboarding of new Test Guideline developers (comtains 4 different modules).

An overview of risk assessment methodology, emphasizing the steps from hazard identification to exposure characterization and the use of scientific evidence in defining safety thresholds.

Discover how Safe and Sustainable by Design (SSbD) combines safety and sustainability for chemicals, materials, and products. This video highlights lifecycle evaluation, key frameworks, and innovative solutions like nano-manufacturing to meet SSbD criteria.

This information map provides an overview of "Safe and Sustainable by Design" (SSbD) for companies developing chemicals and materials. Based on expert input, it includes guidance on SSbD principles and practical tips to help businesses integrate sustainability into their operations.

This video animation presents an introduction to the complexities of making innovation safe by design. It examines the fundamental hurdles and offers a practical overview of risk assessment principles for those developing sustainable and responsible solutions.

A European perspective on workplace risk assessments, featuring presentations on legislation, behavioral approaches, and the OiRA tool to support micro and small businesses.

This seminar discusses in vitro tools to assess toxicology of chemical mixtures.

Presents industry perspectives on QSAR and read-across for regulatory toxicology, focusing on genotoxicity assessment of pesticide residues and the integration of chemical similarity, metabolism, and structural alerts.

Introduces next-generation PBK modeling and its role in translating in vitro concentrations to human-relevant exposures for risk assessment, highlighting key parameters, tools, and case studies.

Covers key features and future plans for the QSAR Toolbox, including integration with IUCLID and applications in non-animal hazard assessment.

Webinar series on exposomics, a growing field studying lifelong exposures and health.

Explore the EU Commission's proposed framework for Safe and Sustainable by Design (SSbD). This workshop discusses its stepwise process, assessment methods, and key aspects of implementation. Case studies and next steps in the criteria’s development are also explored.

The session outlines how stakeholder comments have influenced revisions to the proposed framework. It also includes a presentation of the updated framework and key changes introduced.

The webinar focus on methods to evaluate combined exposures and chemical mixtures, using computer models and in vivo/in vitro testing.

Explores the concept, misconceptions, and future potential of AOPs in predictive toxicology, featuring case studies from nanosafety and discussing their integration with data-driven and high-throughput strategies.

Introduces the fundamentals of deep learning and its application in toxicology, with a focus on model construction, input data handling, and potential uses such as QSAR enhancement.

This handbook provides a comprehensive guide to nanosafety, with sections on data management, nanoinformatics, and emerging topics. Included is a detailed subsection on Safe-and-Sustainable-by-Design (SSbD), addressing the framework for safety and sustainability in material innovation.

Webinar on stakeholder use of the OECD QSAR Toolbox, with insights from OECD and ECHA on its role in REACH and as an alternative to animal testing for chemical assessment.

Explore educational resources on this website to learn about safety in biotechnology and the Safe-by-Design (SbD) approach. Materials are adaptable for use in academic, research, and project contexts, aiding students and researchers in applying SbD principles.

Focuses on risk assessment of combined chemical exposures, highlighting approaches like AOPs, TK/TD models, and in silico methods for regulated products and contaminants.

Covers REACH requirements for QSAR-based adaptations, ECHA’s evaluation approach, and typical deficiencies identified in submitted QSAR studies.

A 50-hour introductory R programming and data analysis course offered in Summer 2021 at Humboldt University zu Berlin. Designed for MSc/PhD biology students with little to no coding experience.

Provides an overview of IUCLID dossier preparation and submission, detailing entities, dataset structure, validation, and the use of ECHA’s Cloud Services.

Focuses on addressing FAIR data challenges in research, highlighting persistent identifiers, metadata, and semantic interoperability through expert presentations and interactive discussions.

Concludes a week-long series of expert discussions with a plenary overview of NanoHarmony’s efforts to support OECD test guideline development, stakeholder collaboration, and long-term regulatory impact for nanosafety.

Discusses the potential of non-animal models to transform safety assessment and therapeutic development, with insights from pandemic-driven advances in regulatory science.

This webpage features Safe-by-Design educational materials developed by RIVM. Resources include an English-language course, serious games, and domain-specific tools for integrating safety into innovation processes. Materials are suitable for curricula or independent use by students and professionals.

A practical guide to navigating FAIR principles, drafting Data Management Plans, and sharing research outcomes, tailored to the needs of diverse research stakeholders.

Presents the RACE tool, supporting exposure assessment for food contaminants by comparing intake estimates with health-based guidance values.

A deep dive into FAIRsFAIR’s work on metadata, semantic interoperability, and persistent identifiers, with insights into aligning technical solutions across European research infrastructures.

This video introduces the concept of Safe-by-Design (SbD) and explores its importance in integrating safety into innovation workflows. Learn how SbD anticipates risks in emerging technologies and helps develop sustainable, responsible, and safe innovations.

Exploring nanoscience in short episodes, this series presents nanoparticles’ fundamentals, addressing topics like risks, applications, and lifecycle stages. Developed with expert input, it offers clear, concise insights for understanding their societal and scientific relevance.

Introduces the Safe Innovation Approach, combining Safe by Design and Regulatory Preparedness to address safety early in the innovation process, with a focus on nanomaterials.

WHO’s Emergency Risk Communication course, outlining key concepts, core modules, and strategies to support effective communication during public health emergencies.