This webstream addresses the role of the SSbD approach in industrial transformation, exploring opportunities, challenges, and its wider uptake at national and regional levels within the chemical sector.

Exclusive content page featuring webinars and workshops on Safe and Sustainable by Design (SSbD), organized as part of INTEGRANO’s SSbD Hub. Registration is required to access recordings and materials from leading experts and EU projects.

This webinar presents an overview of frameworks and methodologies for integrating safety and sustainability in the innovation process for nanomaterials, highlighting tools, systems, and platforms compiled in the recent OECD SSbD report.

Training session on harmonised QA/QC implementation in the PARC project, focusing on consistent approaches to sampling, validation, reporting, and data comparability across diverse chemical monitoring studies.

This presentation explores the production and use of certified reference materials for human biomonitoring, highlighting practical aspects of method validation, sample stability, and traceability in support of EU chemical risk assessment efforts.

The platform highlights structured learning opportunities focused on building expertise in environmental risk assessment methodologies for pharmaceuticals. Through collaborative training and exchange, it contributes to competence development across regulatory, academic, and research communities.

Explore the 2025 SSbD Boot Camp for updates on Safe and Sustainable by Design. Sessions cover the SSbD revision, scoping, safety and sustainability assessments, and documentation, supporting alternatives to substances of concern.

Explore the 2025 SSbD Boot Camp for updates on Safe and Sustainable by Design. Sessions cover the SSbD revision, scoping, safety and sustainability assessments, and documentation, supporting alternatives to substances of concern.

Explore the 2025 SSbD Boot Camp for updates on Safe and Sustainable by Design. Sessions cover the SSbD revision, scoping, safety and sustainability assessments, and documentation, supporting alternatives to substances of concern.

Recording of the 3 July 2025 PARC workshop presenting the alpha release of the SSbD toolbox. Includes an overview of its new interface, core functionalities, and practical use to support implementation of the European Commission’s Safe and Sustainable by Design framework.

Recording from Venice School 2025 provides an introduction to Life Cycle Assessment, highlighting essential methodologies and practical insights for evaluating environmental impacts across a product's lifecycle.

Recording of a Venice School 2025 session introducing a case-specific, quantitative MCDA approach for SSbD. It features methods for identifying multi-optimal solutions and integrating stakeholder perspectives in decision-making.

Presents the use of salivary leukocytes as a non-invasive biomatrix for assessing DNA damage and repair in biomonitoring studies using the comet assay, including methodological optimization and validation of both fresh and cryopreserved samples.

An in-depth look at the development and validation of QSAR models for chemical risk assessment, covering molecular descriptors, statistical modeling techniques, applicability domains, and the principles guiding regulatory acceptance.

This learning material features a collection of recordings from the 2025 Venice Training School, focusing on key aspects of the Safe and Sustainable by Design (SSbD) policy, risk assessment frameworks, and environmental and health evaluation. It includes perspectives on industry uptake, multiscale modelling, decision-support tools, and contributions from the Joint Research Centre (JRC).

This workshop introduces Safe and Sustainable by Design (SSbD) scenarios for advanced and incremental innovations, focusing on tailored approaches for chemical and material risk assessment.

Introduces the principles and applications of Non-Targeted Screening (NTS) using LC-HRMS, with emphasis on broader chemical characterisation, harmonised workflows, and methodological developments in the field.

An overview of in silico approaches in PARC, highlighting VEGA software and integrated platforms for assessing chemical properties aligned with SSbD principles.

This video introduces the Safe-and-Sustainable-by-Design (SSbD) approach in developing nano- and micro-pellets or capsules for cosmetics. Focusing on improved efficacy, controlled release, and sustainable material design.

This video introduces the SSbD framework for University students and researchers, detailing its role in guiding safe and sustainable research and innovation.

The Data Management Tool developed for the INTEGRANO project is presented, highlighting its capacity to manage experimental and logistical data, support FAIR principles, and facilitate collaboration among research partners.

This video introduces the Safe and Sustainable by Design (SSbD) framework for the European textile industry, highlighting strategies for sustainability, regulatory compliance, and innovation across the supply chain.

This video presents an overview of SSbD in the cosmetics sector, focusing on innovation, supply chain impacts, and risk assessment of ingredients and processes.

In this video an introduction to the SSbD Framework is provided, highlighting strategies for integrating safety and sustainability into research and innovation.

Key features of SSbD in wastewater treatment are discussed, including material synthesis, process efficiency, adaptability, and collaboration among stakeholders.

Discover insights into nanomaterials' human and environmental toxicology, as well as of emissions and exposure in all stages of the lifecycle of a nanomaterial. This research supports Safe(r)-and-sustainable-by-design approaches in developing and producing novel materials.

Discover the 2024 Safe and Sustainable by Design (SSbD) Boot Camp, hosted by PARC and AUTH in Thessaloniki. Explore expert presentations, insights into the EU SSbD framework, and discussions on integrating SSbD into research, industry, and innovation.

Discover the 2024 Safe and Sustainable by Design (SSbD) Boot Camp, hosted by PARC and AUTH in Thessaloniki. Explore expert presentations, insights into the EU SSbD framework, and discussions on integrating SSbD into research, industry, and innovation.

Discover the 2024 Safe and Sustainable by Design (SSbD) Boot Camp, hosted by PARC and AUTH in Thessaloniki. Explore expert presentations, insights into the EU SSbD framework, and discussions on integrating SSbD into research, industry, and innovation.

Discover the 2024 Safe and Sustainable by Design (SSbD) Boot Camp, hosted by PARC and AUTH in Thessaloniki. Explore expert presentations, insights into the EU SSbD framework, and discussions on integrating SSbD into research, industry, and innovation.

This webinar explores the exposome framework in toxicology, focusing on multi-stressor interactions, long-term effects, and regulatory implications for environmental health.

Explore the SUNSHINE e-learning focusing on Safe-and-Sustainable-by-Design (SSbD) for advanced nanomaterials. Access recordings and presentations from workshops, webinars, and annual meetings, offering insights into digital tools and sustainability innovations.

Focused on occupational safety, this report explores training needs for workers handling nanomaterials and advanced materials. It includes insights from stakeholder consultations and outlines guidelines for harmonized risk management training across Europe.

Discover the 2023 Safe and Sustainable by Design (SSbD) Boot Camp, hosted by the European Commission Joint Research Centre and PARC. This event offers insights into SSbD, the EU framework, expert-led sessions, and networking opportunities within a growing SSbD community.

Discover the 2023 Safe and Sustainable by Design (SSbD) Boot Camp, hosted by the European Commission Joint Research Centre and PARC. This event offers insights into SSbD, the EU framework, expert-led sessions, and networking opportunities within a growing SSbD community.

Join the 2023 Safe and Sustainable by Design (SSbD) Boot Camp, hosted by the European Commission Joint Research Centre and PARC. This event offers insights into SSbD, the EU framework, expert-led sessions, and networking opportunities within a growing SSbD community.

This webinar presents practical tools and expert insights for industrial adoption of the Safe and Sustainable by Design framework, including case studies and approaches to implementation challenges.

An educational resource offering scientific insights and practical examples on human biomonitoring to support chemical risk assessment and public health decision-making.

Focused on the Safe(r) and Sustainable Innovation Approach (SSIA), this resource explores the integration of safety and sustainability into material design, regulatory anticipation, and collaborative knowledge-sharing frameworks to keep pace with rapid material innovation.

This webinar session introduces the Harmless project's approach to integrating Safe and Sustainable by Design principles in advanced materials, highlighting frameworks, assessment tools, and SME-focused guidance.

Discover how Safe and Sustainable by Design (SSbD) combines safety and sustainability for chemicals, materials, and products. This video highlights lifecycle evaluation, key frameworks, and innovative solutions like nano-manufacturing to meet SSbD criteria.

This information map provides an overview of "Safe and Sustainable by Design" (SSbD) for companies developing chemicals and materials. Based on expert input, it includes guidance on SSbD principles and practical tips to help businesses integrate sustainability into their operations.

This video animation presents an introduction to the complexities of making innovation safe by design. It examines the fundamental hurdles and offers a practical overview of risk assessment principles for those developing sustainable and responsible solutions.

This seminar discusses in vitro tools to assess toxicology of chemical mixtures.

This webinar explores how Safe and Sustainable by Design can be useful for companies, featuring policy and industry perspectives, recent EU developments, and company implementation challenges.

Webinar series on exposomics, a growing field studying lifelong exposures and health.

Explore the EU Commission's proposed framework for Safe and Sustainable by Design (SSbD). This workshop discusses its stepwise process, assessment methods, and key aspects of implementation. Case studies and next steps in the criteria’s development are also explored.

The session outlines how stakeholder comments have influenced revisions to the proposed framework. It also includes a presentation of the updated framework and key changes introduced.

The webinar focus on methods to evaluate combined exposures and chemical mixtures, using computer models and in vivo/in vitro testing.

This handbook provides a comprehensive guide to nanosafety, with sections on data management, nanoinformatics, and emerging topics. Included is a detailed subsection on Safe-and-Sustainable-by-Design (SSbD), addressing the framework for safety and sustainability in material innovation.

Explore educational resources on this website to learn about safety in biotechnology and the Safe-by-Design (SbD) approach. Materials are adaptable for use in academic, research, and project contexts, aiding students and researchers in applying SbD principles.

This webpage features Safe-by-Design educational materials developed by RIVM. Resources include an English-language course, serious games, and domain-specific tools for integrating safety into innovation processes. Materials are suitable for curricula or independent use by students and professionals.

Presents the RACE tool, supporting exposure assessment for food contaminants by comparing intake estimates with health-based guidance values.

This video introduces the concept of Safe-by-Design (SbD) and explores its importance in integrating safety into innovation workflows. Learn how SbD anticipates risks in emerging technologies and helps develop sustainable, responsible, and safe innovations.

Exploring nanoscience in short episodes, this series presents nanoparticles’ fundamentals, addressing topics like risks, applications, and lifecycle stages. Developed with expert input, it offers clear, concise insights for understanding their societal and scientific relevance.

This presentation provides a brief overview of key human biomonitoring (HBM) initiatives worldwide, offering insight into their scope and objectives. It includes a short introduction to the HBM4EU project, highlighting its role in coordinating efforts across Europe to advance the use of HBM in environmental health research and policymaking.

This presentation focuses on the core objectives of the HBM4EU project, providing a comprehensive overview of how each objective aligns with the project's work package structure. It highlights the strategic organisation of HBM4EU's activities and illustrates how the objectives collectively support the development of a coherent and policy-relevant human biomonitoring framework across Europe.

This presentation focuses on the use of blood and urine as primary biological media in HBM, outlining key characteristics of selected biomarkers in each matrix. It provides practical guidance on sample collection methods, highlighting potential pitfalls and necessary contingencies. Strategies for aliquoting and storage are discussed in detail, emphasising the importance of maintaining homogeneity in urine samples and the role of fractionation in sample pretreatment. Considerations for storage conditions, including cooling, freezing, and the use of preservatives, are also addressed to ensure sample integrity.

This presentation focuses on the role of human biomonitoring (HBM) in enhancing chemical risk assessment and supporting evidence-based policymaking. It highlights the need for reliable data on human exposure to chemicals across the EU, including variations over time, geography, and population sub-groups. The presentation also explores how HBM can inform policy by providing tools to interpret exposure data, assess health impacts, and monitor patterns and trends in chemical exposure across Europe.

This presentation focuses on the concept and principles of Human Biomonitoring, specifically the classification and application of biomarkers, distinguishing between those used for exposure assessment, susceptibility evaluation, and research purposes. Highlights how the selection of specific biomarkers can provide insights into bioavailability and bioactivation over time, making them valuable tools for assessing aggregate exposure in diverse populations.

This presentation focuses on exhaled breath condensate (EBC) as a biological matrix for chromium biomonitoring, explaining its production, potential applications, and the procedures for sample collection. It outlines the method developed by the Health & Safety Laboratory in the UK for chromium speciation in EBC, supported by findings from a feasibility study. 

This presentation focuses on the molecular pathways involved in the development of asbestos-related diseases, emphasising the roles of oxidative stress, DNA repair, and xenobiotic metabolism. It explores how both germline mutations and single-nucleotide polymorphisms (SNPs) within these pathways influence individual susceptibility. By understanding these mechanisms, researchers can identify clinically relevant biomarkers that support early diagnosis and risk assessment.

This presentation focuses on the fundamental terminology and principles of sampling, providing a clear overview of key concepts essential for designing and conducting human biomonitoring studies. It includes a brief introduction to the sample selection strategy developed for HBM4EU alignment studies.

This presentation focuses on the basic principles of matrix and biomarker selection in human biomonitoring, guiding participants from the identification of exposure biomarkers to their application in population studies. 

Focuses on the health risks associated with asbestos exposure, emphasizing its link to a range of diseases including asbestosis, pleural conditions, and multiple forms of cancer. Highlights malignant mesothelioma as a particularly aggressive cancer of the pleura and peritoneum, primarily caused by asbestos exposure. Discusses current challenges in diagnosing mesothelioma and the ongoing investigation into potential serum biomarkers, such as Soluble Mesothelin Related Protein (SMRP), Fibulin-3, and Survivin, for improving early detection and monitoring treatment response.

Focuses on exploring the role of gene-environment interactions in disease development, using asbestosis as a case study to illustrate the combined impact of genetic and environmental factors. Highlights findings from a nested case-control study that incorporated cumulative asbestos exposure, smoking data, and PCR-based genotyping, with logistic regression used to assess risk. Emphasises the importance of investigating how genetic factors interact with lifestyle and occupational exposures to shape disease outcomes.

Introduces the Safe Innovation Approach, combining Safe by Design and Regulatory Preparedness to address safety early in the innovation process, with a focus on nanomaterials.

This SOP focuses on standardising dermal exposure assessment to total chromium through wipe sampling, based on established IOM procedures and OSHA Method ID-125G guidelines. The protocol utilises SKC Ghost wipes to collect representative samples of hand contamination, supporting consistent and reliable monitoring of metals such as chromium, zinc, nickel, and hydrocarbons across different exposure scenarios.