Presents the use of salivary leukocytes as a non-invasive biomatrix for assessing DNA damage and repair in biomonitoring studies using the comet assay, including methodological optimization and validation of both fresh and cryopreserved samples.

An in-depth look at the development and validation of QSAR models for chemical risk assessment, covering molecular descriptors, statistical modeling techniques, applicability domains, and the principles guiding regulatory acceptance.

An overview of in silico approaches in PARC, highlighting VEGA software and integrated platforms for assessing chemical properties aligned with SSbD principles.

Discusses the potential of non-animal models to transform safety assessment and therapeutic development, with insights from pandemic-driven advances in regulatory science.

This presentation focuses on the molecular pathways involved in the development of asbestos-related diseases, emphasising the roles of oxidative stress, DNA repair, and xenobiotic metabolism. It explores how both germline mutations and single-nucleotide polymorphisms (SNPs) within these pathways influence individual susceptibility. By understanding these mechanisms, researchers can identify clinically relevant biomarkers that support early diagnosis and risk assessment.