Key messages To address current gaps in test strategies for chemical-induced liver toxicity, this project will support regulatory assessments by integrating sex-specific biological differences into in vitro liver models: to improve mechanistic understanding of sex-specific mechanisms of liver toxicity; to enhance human relevance and equity of chemical safety assessments through...

Key messages Regulation on the content and amounts of chemicals in consumer products and materials is a key part of ensuring chemical safety. Enforcement of such regulations requires appropriate analytical tools to monitor compliance in products on the market, as well as support producers and importers in ensuring their products...

Overview This project develops and tests an Adverse Outcome Pathway ( AOP) network approach to identify thyroid hormone system disrupting chemicals (THSDCs) in fish. It fills critical gaps in current tools by integrating in silico, in vitro, and in vivo fish test data within a tiered testing strategy aligned with...

Key messages Novel approaches for assessing chemical exposure bring significant progress in detecting chemical burden, but challenges remain due to the complexity of chemical behaviour and the limitations of covering the entire chemical space. Some chemicals metabolise rapidly or accumulate in tissues not routinely investigated in classical human biomonitoring, risking...

Overview This project investigates how levels of internal exposure to environmental pollutants have changed over time across Europe. It builds on data collected from children, teenagers, and adults through previous and ongoing human biomonitoring (HBM) studies under HBM4EU and PARC. The main goal is to assess exposure trends and evaluate...

Key messages By targeting children aged 6–11 across several European countries, the project provides crucial insights into PFAS exposure during a sensitive developmental stage for which data is lacking. The use of aligned protocols and tools from the PARC Aligned Studies ensures data comparability and reliability across participating countries. The...

Key messages Holistic PFAS biomonitoring in early development stage Monitoring of newborns and pregnant women PFAS exposure and pahtway gaps to be filled Potential refinement of regulatory thresholds Overview This project implements a longitudinal human biomonitoring (HBM) survey to investigate exposure to per- and polyfluoroalkyl substances ( PFAS) in the...

Key messages It is critical that incorporation of New Approach Methodologies ( NAMs) data in chemical risk assessments is transparent and follows structured processes to make it possible for decision-makers to use assessments based on such data in their work. Study validity assessment constitutes a retrospective validation of existing data...

Overview This project focuses on improving how to assess the safety of chemical by applying advanced scientific methods that reduce the need for animal testing. It is supporting regulatory decisions by identifying chemicals that may harm human health or the environment. The central focus is using the Adverse Outcome Pathway...

Overview Enhancing the transparency and acceptance of artificial intelligence (AI) and machine learning (ML) techniques in chemical risk assessment is the focus of this initiative. With an increasing reliance on these advanced methods for predicting chemical behaviour and assessing risks, addressing the challenges posed by unclear documentation and limited access...

Overview This project is developing physiologically based kinetic (PBK) models to better predict how chemicals behave in the human body, i.e. to predict their absorption, distribution, metabolism and excretion (ADME). By performing quantitative in vitro to in vivo extrapolation (QIVIVE) and providing a link with Adverse Outcome Pathways ( AOPs)...

Key messages The project houses different case studies on environmental burden of disease (EBD) of chemicals. FAIRification of data applied in the case studies is a must. Identification of datagaps on exposure, exposure-response and health outcomes is included in the lessons learnt from the case studies. Overview To protect people’s...

Key messages Health impact assessment is a tool that provides policymakers with insights into the health burden that is attributable to chemical exposures and helps them to prioritise preventive measures. Improved methodologies and data are needed to reduce uncertainties of the estimated health impacts. Overview Environmental Burden of Disease (EBD)...

Key messages Mode of action data and curated effect concentrations for more than 3300 environmentally relevant chemicals are provided as FAIR data set for mixture risk assessments. 80 chemicals are ubiquitously released by European waste-water treatment plants and provide a cross-regulation mixture that should be regulated as background baseline pollution...

Key messages Current biomonitoring methods are limited in assessing the full spectrum of chemical exposures, especially with emerging chemicals in occupational sectors. Innovative screening methods (SS/NTS) and new sampling tools (DBS, SWB) offer a promising alternative to traditional approaches, enabling more comprehensive exposure assessment. The project will demonstrate the proof...

Overview Establishing a process for environmental and multisource monitoring is a key focus of the PARC initiative. This process aims to support the European Union's chemical risk assessment efforts by addressing two main areas: (i) environmental ecosystems and (ii) human exposure, closely linked to human biomonitoring. Building on existing structures...

Overview Every day, chemicals are released into the environment leading to human exposure (e.g. through the food we eat, the air we breathe, and the products we use) and exposure of natural animal and plant populations. Many of these substances can interfere with hormone systems, potentially affecting our health and...

Key messages The project applied an expert consultation in the form of a systematic literature review, qualitative interviews and a survey with risk assessors in Europe. The following are the key messages from the project. Improve familiarity and use of NAMs in regulatory risk assessment by showcasing success stories and...

Key messages The developing immune system is highly sensitive and vulnerable to harmful substances in the environment- This project will help create better (non-animal) testing methods to detect and understand these risks and protect immune health. Overview This project expands the ongoing PARC immunotoxicity work to focus on the effects...

Key messages Human biomonitoring (HBM) data are being used to calculate the health impact of chemical exposure. Risk indicators as percentage of exceedance, extent of exceedance gives information if and how much human biomonitoring guidance values are breached or not. Indicators on burden of disease as attributable cases or disability...