Key messages The project addresses critical gaps in developmental and reproductive toxicology (DART-ED) assessment by advancing mechanistic understanding and New Approach Methodologies ( NAMs) development across EATS (Estrogen, Androgen, Thyroid, Steroidogenesis) and non-EATS modalities. It supports regulatory needs by developing NAMs that integrate multiple endocrine pathways and life stage vulnerabilities...

Overview The project supports the regulatory uptake of New Approach Methodologies ( NAMs) for toxicological hazard and chemical safety assessment. Currently, most chemical regulations rely on OECD test guideline assays, whose validation follows OECD Guideline 34, now under revision. One of PARC’s central goals is to enable the transition of...

Key messages Harmonisation of methods and safe concentrations for indoor air pollutants Prioritisation of chemical pollutants Guidance for interpreting indoor air monitoring data Supporting risk managers striving towards improving air quality in indoor environments in Europe Overview Indoor air quality is a growing health concern, particularly as people spend up...

Overview Skin sensitisation, an allergic response to chemicals following repeated skin contact, affects over 25% of the European adult population. Despite its prevalence, the European Union lacks a standardised risk assessment model for regulatory use. Current gaps in understanding include how complex mixtures of allergens and irritants, commonly found in...