Background and Aims: Drug-induced liver injury (DILI) is one of the most frequentreasons for failure of drugs in clinical trials or market withdrawal. Early assessmentof DILI risk remains a major challenge during drug development. Here, we presenta mechanism-based weight-of-evidence approach able to identify certain candidatecompounds with DILI liabilities due to...

Nephrotoxicity caused by drug or chemical exposure involves complex mechanisms as well as a temporal integration of injury and repair responses in different nephron segments. Distinct cellular transcriptional programs regulate the time-dependent tissue injury and regeneration responses. Whole kidney transcriptome analysis cannot dissect the complex spatio-temporal injury and regeneration responses...

Context In vitro toxicity studies are increasingly being included as evidence in systematic reviews and chemical risk assessments. INVITES-IN, a tool for assessing the internal validity of in vitro studies, is under development in a process consisting of four consecutive studies. Study One in the creation of INVITES-IN was the...

Bisphenol A (BPA) is a well-known endocrine disruptor linked to numerous adverse health outcomes and was, therefore, banned in food-contact materials in the European Union. Numerous alternatives are now in commerce, but their health hazards are often inadequately addressed. This study compared BPA and 26 alternatives in six in vitro...