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News

PARC launches new strategic projects to strengthen regulatory chemical risk assessment

Starting in May 2026, PARC will initiate a new portfolio of strategic projects. These initiatives aim to further advance chemical risk assessment in Europe by integrating new approach methodologies (NAMs), developing advanced toxicological and exposure models, and strengthening the scientific basis for European regulatory decision-making. Together, these projects reflect PARC’s...

PARC supports the implementation of the EU’s “One Substance, One Assessment” legislative package

The European Union is entering a new phase in its chemicals policy with the forthcoming “One Substance, One Assessment” ( OSOA) Regulation, a major reform designed to streamline chemical risk assessment across Europe with initial discussions in 2023. After several years of preparation and political negotiation, the OSOA package has...

chemical leaders

Meet the PARC Chemical Leaders

As part of its mission to strengthen Europe’s capacity to assess, monitor and reduce chemical risks, the Partnership for the Assessment of Risks from Chemicals (PARC) has completed a dedicated campaign of interviews with its Chemical Leaders, the experts guiding scientific progress across PARC’s priority areas. This series brings visibility...

data management plan

PARC Data Management Plan named “essential reading” by external reviewers

While Data Management Plans (DMPs) are often perceived by researchers as an administrative burden or an afterthought to research activities, it is increasingly recognised that best research practice requires data to be made available to others. Crucially, this must be done with sufficient information on research context and provenance to...

224 results

Events

Winter Meeting 2026 – Norwegian Society for Pharmacology and Toxicology

The Winter Meeting 2026, organised by the Norwegian Society for Pharmacology and Toxicology (NSFT), serves as a platform for pharmacologists, toxicologists, regulatory scientists, and related professionals to share their research, discuss emerging science and methodologies, and foster collaboration within the Nordic toxicology and pharmacology communities. The winter meeting will feature...

Experimental Design and Analysis of Multivariate Data

The Advanced Course on Experimental Design and Analysis of Multivariate Data (EDAMD) will take place in person from 23 to 27 February 2026, hosted by the University of Aveiro. The course will combine theoretical and practical sessions in a problem-solving format. Participants will be introduced to key concepts in multivariate...

Systematic Reviews for Complex Interventions in Medicine and Public Health

The course on Systematic Reviews for Complex Interventions in Medicine and Public Health is a four-day training designed to introduce advanced methods for conducting systematic reviews and evidence synthesis in the context of complex medical and public health interventions. The course will explore how multiple interacting components and context dependency...

Advanced Systematic Reviews and Meta-Analysis

This 3-day virtual course introduces advanced methods for systematic reviews and meta-analysis, combining frequentist and Bayesian approaches with hands-on computer exercises. It covers planning and conducting meta-analyses, network and diagnostic meta-analysis, heterogeneity assessment, and applications in HTA and clinical decision making. The program includes expert-led lectures, practical tutorials, and comprehensive...

83 results

Projects

Improving chemical risk assessment with new approach methods

Key messages The project applied an expert consultation in the form of a systematic literature review, qualitative interviews and a survey with risk assessors in Europe. The following are the key messages from the project. Improve familiarity and use of NAMs in regulatory risk assessment by showcasing success stories and...

Advancing chemical risk assessment for diverse populations

Overview Physiologically Based Pharmacokinetic modelling is a method that uses mathematical representations of the body’s biological processes to predict how chemicals are absorbed, distributed, metabolised, and excreted in different tissues and organs. It plays a crucial role in evaluating how chemicals interact with the body, helping researchers to understand how...

Innovative testing strategies for the developing immune system

Key messages The developing immune system is highly sensitive and vulnerable to harmful substances in the environment- This project will help create better (non-animal) testing methods to detect and understand these risks and protect immune health. Overview This project expands the ongoing PARC immunotoxicity work to focus on the effects...

Hazard characterisation of emerging mycotoxins

Key messages Identifying toxicological effects of selected enniatins and Alternaria toxins. Providing urgently needed in vitro data for an appropriate risk assessment. Aim to set health-based guidance values for food (and feed). Overview Mycotoxins are secondary metabolites produced by fungi that can contaminate food (e.g. cereal products, fruits, and beverages)...

166 results

Publications

Report of the European Commission workshop on "The roadmap towards phasing out animal testing for chemical safety assessments", Brussels, 11–12 December 2023

Report of the European Commission workshop on "The roadmap towards phasing out animal testing for chemical safety assessments", Brussels, 11–12 December 2023

This report summarises the main findings and discussion from the European Commission (EC) workshop on “The Roadmap Towards Phasing Out Animal Testing for Chemical Safety Assessments” which was held in Brussels on 11–12 December 2023. The aim of the workshop was to gather ideas and opinions from individuals, organisations and...

Hazard characterization of the mycotoxins enniatins and beauvericinto identify data gaps and improve risk assessment for human health

Hazard characterization of the mycotoxins enniatins and beauvericin to identify data gaps and improve risk assessment for human health

Enniatins (ENNs) and beauvericin (BEA) are cyclic hexadepsipeptide fungal metabolites which have demonstrated antibiotic, antimycotic, and insecticidal activities. The substantial toxic potentials of these mycotoxins are associated with their ionophoric molecular properties and relatively high lipophilicities. ENNs occur extensively in grain and grain-derived products and are considered a food safety...

Evaluating PFAS-Induced modulation of peripheral blood mononuclear cells (PBMCs) immune response to SARS-CoV-2 spike in COVID-19 Vaccinees

Evaluating PFAS-Induced modulation of peripheral blood mononuclear cells (PBMCs) immune response to SARS-CoV-2 spike in COVID-19 Vaccinees

The persistent nature of the environmental contaminants per- and polyfluoroalkyl substances (PFAS) has recently received considerable attention, particularly because of their adverse effects on immune system functionality in the context of vaccine responses to infectious diseases. Following COVID-19 vaccination, some studies have shown a significant negative correlation between serum PFAS...

Modeling zebrafish escape swim reveals maximum neuromuscular power output and efficient body movement adaptation to increased water viscosity

Modeling zebrafish escape swim reveals maximum neuromuscular power output and efficient body movement adaptation to increased water viscosity

Under evolutionary pressure, the kinematic and energetic characteristics of animal locomotion have been optimized for survival. We investigated the kinematics and energetic performance of zebrafish eleutheroembryo escape swims triggered by electrical stimuli in fluids of increasing viscosity. Eleutheroembryos exhibited a decrease in both tail movement frequency and swimming velocity in...

78 results

Deliverables

First PARC Exit Strategy Plan and sustainability report

First annual CL/ML reports' coordination and submission

Report on current screening and enforcement structures

First report on New Approach Methodologies

99 results

Learning materials

Training on the Collection of Exhaled Breath Condensate

This presentation focuses on exhaled breath condensate (EBC) as a biological matrix for chromium biomonitoring, explaining its production, potential applications, and the procedures for sample collection. It outlines the method developed by the Health & Safety Laboratory in the UK for chromium speciation in EBC, supported by findings from a...

Genetic variability and the risk of developing asbestos related diseases

This presentation focuses on the molecular pathways involved in the development of asbestos-related diseases, emphasising the roles of oxidative stress, DNA repair, and xenobiotic metabolism. It explores how both germline mutations and single-nucleotide polymorphisms (SNPs) within these pathways influence individual susceptibility. By understanding these mechanisms, researchers can identify clinically relevant...

Taking a representative sample for all age groups

This presentation focuses on the fundamental terminology and principles of sampling, providing a clear overview of key concepts essential for designing and conducting human biomonitoring studies. It includes a brief introduction to the sample selection strategy developed for HBM4EU alignment studies.

Ethics and health information including genetic testing

Focuses on key ethical and legal considerations involved in the collection of health information. It provides an introduction to the regulatory frameworks that govern the use of health data, highlighting the importance of accountability and compliance in research.

203 results

Partners

General Chemical State Laboratory

Tsocha 16, Athina 115 21

Luxembourg Institute of Health

1A-B, rue Thomas Edison, L-1445

Norwegian Institute of Public Health

Lovisenberggata 8, 0456

Lisbon School of Medicine

Avenida Professor Egas Moniz, 1649-028 Lisboa

251 results

Laboratories

Medical University of Vienna

Währinger Straße 10, 1090 Wien

French National Research and Safety Institute for the Prevention of Occupational Accidents and Diseases (INRS)

1, rue du Morvan - 54519 Vandoeuvre-lès-Nancy

Vandœuvre-lès-Nancy

European Molecular Biology Laboratory – European Bioinformatics Institute (EMBL-EBI)

EMBL-EBI Main Building, Wellcome Genome Campus, Hinxton CB10 1SD

Michabo Health Science

Union House, 111 New Union Street, Coventry CV1 2NT