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News

Two PARC-Affiliated Researchers Recognised

Two PARC-affiliated early-career researchers recognised with major toxicology awards

Three early-career researchers collaborating with PARC have recently been honoured at important scientific meetings in the field of toxicology. Their achievements highlight both the quality of their work and the value of international cooperation in advancing research that protects human health. Sebastian Gutsfeld, a PhD researcher working in the group...

Training - 3rd in silico models and read-across

Join the PARC remote course on in silico models and read-across using VEGAHUB (2nd edition)

PARC is organising the second edition of the remote training course on “Exercises on results of in silico models and read-across using VEGAHUB – Examples related to cosmetics and ecotoxicological and environmental properties”, continuing its series of hands-on trainings focused on the practical interpretation and application of in silico tools...

WP6 Workshop 2026

WP6 Workshop 2026 in Brussels highlights progress on regulatory relevance, innovation and collaboration

The WP6 Workshop 2026, held in Brussels, brought together participants for several days of discussion, exchange and practical work focused on strengthening the regulatory relevance of research within PARC’s integrative risk assessment activities. The meeting opened with strategic presentations that helped frame the key challenges and opportunities ahead. Among them...

PARC&JRC. Annual Meeting 2026

PARC and JRC strengthen collaboration at Annual Meeting 2026

PARC and the European Commission’s Joint Research Centre (JRC) met online on 24 February 2026 for their annual meeting, bringing together around 40 PARC representatives and 20 JRC participants. The meeting provided an opportunity to review ongoing joint work, share updates on PARC activities, and identify new areas for collaboration...

224 results

Events

Webinar on Persistent and Pervasive PFAS—A Global Perspective: Part 1

This opening webinar in the 2026 IUTOXtalks series explores the global challenges associated with per- and polyfluoroalkyl substances (PFAS), combining mechanistic science with human exposure evidence. Prof. Emanuela Corsini will present on the immunotoxic effects of PFAS using human-relevant models and model systems, while Prof. Angela Slitt will examine the...

Exercises on results of in silico models and read-across using VEGAHUB – Examples related to cosmetics and ecotoxicological and environmental properties

PARC is organising the second edition of the remote training course on “Exercises on results of in silico models and read-across using VEGAHUB – Examples related to cosmetics and ecotoxicological and environmental properties”, continuing its series of hands-on trainings focused on the practical interpretation and application of in silico tools...

74th ASMS Conference on Mass Spectrometry and Allied Topics – Advances in Mass Spectrometry for Science and Society

The 74 th ASMS Conference on Mass Spectrometry and Allied Topics, organised by the American Society for Mass Spectrometry, is one of the world’s leading scientific events dedicated to mass spectrometry and its broad range of applications. The conference brings together researchers, instrument developers, industry experts, and policymakers to explore...

18th National Congress of the Spanish Society of Environmental Health – Evidence and action for a sustainable future

The 18 th National Congress of the Spanish Society of Environmental Health (SESA) is a leading national event dedicated to promoting scientific exchange and innovation in environmental health. Bringing together researchers, public health professionals, policymakers, laboratory experts, and other stakeholders, the meeting will address current challenges and emerging priorities in...

17 results

Thematic areas

Science to policy:

PARC is inviting the whole community of professionals in chemical risk assessment in Europe and worldwide to share their knowledge and ideas on the PARCopedia platform launched in November 2023. PARCopedia is a not-for-profit, ad-free knowledge management and social media environment.

Science to policy:

Science to policy dialogue network

We are connecting PARC partners and external stakeholders, from both the research and the regulatory domains, to apply the long-term visions of the European policies related to chemical safety.

Building infrastructure and human capacities:

Stay up to date on the latest trainings in the field of environmental monitoring and biomonitoring of chemicals to improve the overall quality of chemical risk assessment and management globally.

Building infrastructure and human capacities:

Online catalogues on exposure monitoring

Check our mapping and cataloguing environmental (air, water/sediment, soil, biota, drinking water, food & feed) monitoring networks as well as the gaps and opportunities for future alignment.

83 results

Projects

In vitro methods to assess respiratory uptake and toxicity

Overview Inhalation is an important but often not assessed route of chemical exposure, alongside dermal and oral pathways. This project addresses the current gap by developing in vitro models to assess how chemicals are absorbed, accumulated, and transported through respiratory tissues. The focus is on two key chemical groups pesticides...

Establishment of advanced data processing methodologies and bioinformatic tools for a non-targeted screening repository

Overview Across Europe, thousands of chemicals are currently present in consumer products, the environment, and food chains. Yet, for many of these substances, limited or no information is available regarding human and environmental exposure. This substantial data gap poses a serious challenge to policymakers, who require robust evidence to assess...

Beyond food: Organic contaminants in daily environments

Key messages Non-food exposure pathways: Humans are significantly exposed to organic contaminants through indoor air, dust, drinking water, and soil – pathways that are not systematically monitored like food. Linking exposure data: The project aims to connect internal human biomonitoring data with external environmental exposure, enhancing interpretation and risk assessment...

Toxicity of plastic-associated chemicals

Overview Plastics might contain thousands of chemicals, many of which remain unregulated and poorly understood. Recent studies, including the PlastChem project, reveal over 16,000 chemicals in plastic materials, with only 6% currently regulated. Notably, around 4,200 chemicals are known to be hazardous, while hazard data is entirely missing for more...

166 results

Publications

New approach methodologies to enhance human health risk assessment of immunotoxic properties of chemicals — a PARC (Partnership for the Assessment of Risk from Chemicals) project

New approach methodologies to enhance human health risk assessment of immunotoxic properties of chemicals — a PARC (Partnership for the Assessment of Risk from Chemicals) project

As a complex system governing and interconnecting numerous functions within the human body, the immune system is unsurprisingly susceptible to the impact of toxic chemicals. Toxicants can influence the immune system through a multitude of mechanisms, resulting in immunosuppression, hypersensitivity, increased risk of autoimmune diseases and cancer development. At present...

Exploring the genotoxic potential of bisphenol A and its emerging alternatives in an advanced in vitro 3D zebrafish hepatic cell model

Exploring the genotoxic potential of bisphenol A and its emerging alternatives in an advanced in vitro 3D zebrafish hepatic cell model

With global restrictions on Bisphenol A (BPA), various BPA alternatives are increasingly found in ecosystems, raising concerns. This study focuses on the genotoxic potential of three emerging BPA alternatives — Bisphenol AF (BPAF), Bisphenol AP (BPAP), and Bisphenol PH (BPPH) — using an advanced in vitro 3D model system, spheroids...

Physiologically based kinetic (PBK) modeling as a new approach methodology (NAM) for predicting systemic levels of gut microbial metabolites

Physiologically based kinetic (PBK) modeling as a new approach methodology (NAM) for predicting systemic levels of gut microbial metabolites

There is a clear need to develop new approach methodologies (NAMs) that combine in vitro and in silico testing to reduce and replace animal use in chemical risk assessment. Physiologically based kinetic (PBK) models are gaining popularity as NAMs in toxico/pharmacokinetics, but their coverage of complex metabolic pathways occurring in...

The European Partnership PARC’s role in actively promoting the uptake of new approach methodologies and next-generation risk assessment into regulatory risk assessment practice

The European Partnership PARC's role in actively promoting the uptake of new approach methodologies and next-generation risk assessment into regulatory risk assessment practice

Existing approaches for human health risk assessment of chemicals have overall provided a high level of protection for EU citizens. However, the established assessment schemes face numerous challenges. Ethical and scientific concerns about using animals for safety testing have triggered awareness of the need for a paradigm shift, requiring new...

78 results

Deliverables

Innovative analytical and uncertainty approaches

Data infrastructure tools and services

First report on health impact indicators and their policy implications

First report on innovative approaches for real-life mixture risk assessment

20 results

Indicators

Number of external initiatives seeking synergies with PARC

Would you like to collaborate with us? Learn more about synergies in our project here.

Expertise covered by the national hubs

Number of external laboratory networks catalogued

Number of entities in the PARC laboratory networks

99 results

Learning materials

JRC SSbD Bootcamp 2025- day 3

Explore the 2025 SSbD Boot Camp for updates on Safe and Sustainable by Design. Sessions cover the SSbD revision, scoping, safety and sustainability assessments, and documentation, supporting alternatives to substances of concern.

JRC SSbD Bootcamp 2025 - day 2

Explore the 2025 SSbD Boot Camp for updates on Safe and Sustainable by Design. Sessions cover the SSbD revision, scoping, safety and sustainability assessments, and documentation, supporting alternatives to substances of concern.

JRC SSbD Bootcamp 2025 - day 1

Explore the 2025 SSbD Boot Camp for updates on Safe and Sustainable by Design. Sessions cover the SSbD revision, scoping, safety and sustainability assessments, and documentation, supporting alternatives to substances of concern.

NSC workshop on "SSbD scenarios for advanced and incremental innovations"

This workshop introduces Safe and Sustainable by Design (SSbD) scenarios for advanced and incremental innovations, focusing on tailored approaches for chemical and material risk assessment.

203 results

Partners

University of Bath

Claverton Down, BA2 7AY

University of Aberdeen

King's College, AB24 3FX

University College London

Gower Street, WC1E 6BT

University of Birmingham

Edgbaston, B15 2TT

251 results

Laboratories

University of Thessaly

Biopolis Campus, 415 00, Larissa

Public Health Authority of the Slovak Republic

Trnavská cesta 52, 826 45 Bratislava

ProtoQSAR, S.L.

Carrer de Nicolau Copèrnic, 6, 46980 Paterna

Slovak Medical University in Bratislava (SMU)

Limbová 12, 833 03 Bratislava

18 results

Other content

Parc advising bodies

Governance structure Use the interactive map above to discover the governance structure of P-A-R-C. International Board (IB): The IB contributes to the science-to-policy dialogue, identification of synergies & collaborations, contribution on open science, new approaches. The IB includes experts from other international chemical risk assessment platforms, scientific advisory boards and...

Parc management bodies

Governance structure Use the interactive map above to discover the governance structure of P-A-R-C. Management Board (MB): The MB is the operational body that supports the Coordinator in the day-to-day implementation of the Grant Agreement based on the Description of Action and Annual Work Plans. The MB includes the Coordinator...

coordination-and-exchange

Governance structure Use the interactive map above to discover the governance structure of P-A-R-C. National Hubs (NHs): Countries involved in PARC establish and extend the NHs created to develop collaboration and contribute to ensuring PARC’s activities are aligned with national activities. There are no prescriptive rules and the construction is...

Contacts list Work Package (WP) and Task (T) Leaders WP1 “Partnership Management and Coordination” PARC Coordination Team ( parc

anses [dot] fr) Pascal Sanders (ANSES; pascal [dot] sanders

anses [dot] fr) Christophe Rousselle (ANSES; christophe [dot] rousselle

anses [dot] fr) T1.1 “Overall executive management and support of the Partnership” Christophe Rousselle (ANSES; christophe [dot] rousselle

anses [dot] fr) PARC Coordination Team ( parc

anses [dot] fr) T1.2 “Scientific steering and implementation...