The webinar Translating in vitro mechanistic findings to in vivo toxicity outcomes: A case study of Usnic acid hepatotoxicity will take place on 11 June 2026 at 16:00 CET. The session will explore how New Approach Methodologies (NAMs), quantitative in vitro–to–in vivo extrapolation (QIVIVE), and physiologically based pharmacokinetic (PBPK) modelling can be used to translate mechanistic laboratory findings into meaningful human health risk assessment outcomes. Using usnic acid hepatotoxicity as a case study, the webinar will demonstrate how mechanistic evidence can support next-generation safety assessments of botanical constituents.

Target audience
This webinar is particularly relevant for toxicologists, risk assessors, regulatory scientists, pharmacokinetic modellers, NAM developers, academic researchers, and professionals involved in botanical safety evaluation, chemical safety assessment, and regulatory toxicology. The webinar is open to all interested participants, although prior registration is required.