Key messages

• Re-Mix advances the risk assessment and management of chemical mixtures to better protect the environment and human health.
• Re-Mix focuses on different options to integrate mixture risks assessment and management strategies in different regulatory frameworks and comes up with scientific analyses and proposals (e.g. the use of component-based approaches and/or a mixture allocation factor).
• Re-Mix will foster accessibility, development and use of feasible methodologies, tools and data for mixture risk assessments.
• Re-Mix will provide a better knowledge on the extent of mixture risks due to co-exposures of chemicals in different environmental areas (e.g. marine waters, soil, freshwater) and for human health.

Overview

This project supports the development of a harmonised strategy for assessing and regulating chemical mixtures. It builds on the results of the OPREMIX and MONNAMMIX projects, which conclude in August 2025. It brings together experienced partners and leverages earlier outcomes such as the comparative evaluation of existing mixture assessment tools, systematic assessments of the feasibility of a Mixture Assessment Factor (MAF) Mixture Assessment Factor (MAF) approach, data analyses to estimate the magnitude of mixture risks in different areas (environmental compartments and human health) and proposals for draft frameworks for an improved mixture regulation.

RE-MIX will further develop case studies and provide practical insights to improve mixture risk assessment (MRA) ↗ in line with evolving EU regulatory frameworks, including the REACH ↗ revision, EFSA ↗ guidance on soil risk, and the WFD CIS programme ↗ (2025–2027). The project aims to address several PARC research needs, notably co-exposure to multiple chemicals, while also contributing to work on chemicals and biodiversity and on endocrine disruptor mixtures.

Through the involvement of national agencies collaboration with EU agencies such as EFSA, ECHA ↗, and EEA ↗, RE-MIX will help identify further MRA needs and ensure that methods and case studies remain relevant for real-world regulatory decision-making.

The project will enhance the development and implementation of robust tools, monitoring strategies, and guidance, aligning with the overarching goal of improving chemical safety and protecting both human health and the environment.

Achievements & Results

• The minutes of the Kick-off in May 2025 in Viena as well as a follow up project meeting in July 2025 are available and provide an overview on aims, important discussion points and the planned case studies.
• This section will be complemented when results available.

Policy relevance

To substantiate decisions on the policy level with respect to risk management options and adaptation of EU legislations, detailed knowledge on the available options and evidence on the magnitude of the “problem” is needed. Here, Re-Mix will support with analyses and recommendations from regulatory science as well as evidence from data analyses together with the development and check of feasible tools and data for regulatory use. Tight cooperation with national agencies as well as EFSA, ECHA, EEA and JRC ↗ via e.g. a regulatory steering group is envisaged.