PARC Projects

Provide protection against most harmful chemicals
Shift away from animal testing
Skin sensitisation and mixtures effects
Health effects
Human health
Mixtures
NGRA
Time span
-
Partners involved
REGIONH (DK)
STAMI (NO)
UCPH (DK)
AGES (AT)
Contacts
Jeanne Duus Johansen (REGIONH)
Jeanne.Duus.Johansen [at] regionh.dk
Jose Hernán Alfonso (STAMI)
jose.alfonso [at] stami.no
Overview

Skin sensitisation ↗, an allergic response to chemicals following repeated skin contact, affects over 25% of the European adult population. Despite its prevalence, the European Union lacks a standardised risk assessment model for regulatory use. Current gaps in understanding include how complex mixtures of allergens and irritants, commonly found in consumer and occupational products, influence the immune response and increase sensitisation risk. This lack of harmonised evaluation leads to uncontrolled exposure and inconsistent regulatory decisions.

This project seeks to address these issues by assessing the applicability of New Approach Methods (NAMs ↗) for evaluating the sensitisation potential of defined mixtures. Although some NAMs, including in chemico and in vitro approaches, are accepted for single substance classification (OECD TG 497 ↗), their use for mixtures remains unexplored.

Using advanced 3D skin models that better replicate human skin, the study will evaluate the performance of selected NAMs in predicting mixture effects and provide insights into underlying mechanisms.

Outcomes are expected to inform the development of improved predictive models and contribute to regulatory frameworks for skin sensitisation, particularly for mixtures. Ultimately, the project supports the advancement of non-animal testing strategies and enhances protection of public health.

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Mixtures
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Workers
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Skin sensitisation and mixtures effects

Time span
-
REGIONH (DK)
STAMI (NO)
UCPH (DK)
AGES (AT)
Overview

Skin sensitisation ↗, an allergic response to chemicals following repeated skin contact, affects over 25% of the European adult population. Despite its prevalence, the European Union lacks a standardised risk assessment model for regulatory use. Current gaps in understanding include how complex mixtures of allergens and irritants, commonly found in consumer and occupational products, influence the immune response and increase sensitisation risk. This lack of harmonised evaluation leads to uncontrolled exposure and inconsistent regulatory decisions.

This project seeks to address these issues by assessing the applicability of New Approach Methods (NAMs ↗) for evaluating the sensitisation potential of defined mixtures. Although some NAMs, including in chemico and in vitro approaches, are accepted for single substance classification (OECD TG 497 ↗), their use for mixtures remains unexplored.

Using advanced 3D skin models that better replicate human skin, the study will evaluate the performance of selected NAMs in predicting mixture effects and provide insights into underlying mechanisms.

Outcomes are expected to inform the development of improved predictive models and contribute to regulatory frameworks for skin sensitisation, particularly for mixtures. Ultimately, the project supports the advancement of non-animal testing strategies and enhances protection of public health.

Contacts
Jeanne Duus Johansen (REGIONH)
Jeanne.Duus.Johansen [at] regionh.dk
Jose Hernán Alfonso (STAMI)
jose.alfonso [at] stami.no
Topics
Provide protection against most harmful chemicals
Shift away from animal testing
Keywords
Health effects
Human health
Mixtures
NGRA

Related Projects

Enhancing data integration and risk assessment for chemical exposure