People can be exposed to arsenic through drinking water from contaminated wells, through certain foods like rice and some seafood, and through air or soil near industrial sites or old mining areas.
Chemicals
Health effects
Related questions
Long‑term exposure to inorganic arsenic can damage many organs, leading over time to skin changes (such as dark spots or thickened skin), and increasing the risk of cancers of the skin, lungs, and bladder, as well as heart disease and diabetes.
Yes, EU law sets a maximum of 10 micrograms of arsenic per litre in drinking water, and specific maximum levels for inorganic arsenic in foods like rice, rice‑based drinks, salt, and foods for infants and young children.
Related questions
BPA is a chemical used to make hard plastics and can linings, and it was banned from baby bottles in the EU because it can mimic hormones and small babies are particularly vulnerable to its possible effects on development.
Bisphenol S (BPS) and bisphenol F (BPF) are often used instead of BPA, but scientific studies show they can also act like hormones, so there is concern that simply swapping BPA for these similar chemicals does not fully solve the problem.
Bisphenols have been linked to possible effects on fertility, changes in thyroid and reproductive hormones, and an increased risk of obesity and some metabolic diseases, although the exact risks at low everyday exposures are still being studied.
Related questions
Health agencies in Europe advise most adults to eat fish regularly but to limit large predatory species like shark, swordfish, and some big tuna, and recommend that pregnant women and young children choose smaller, low‑mercury fish such as salmon, sardines, and herring.
Dental amalgam fillings contain mercury, but for most people the small amounts of mercury vapour released are considered low risk; however, the EU is phasing out dental amalgam to reduce overall mercury pollution.
The EU has strict limits on mercury emissions to air from industrial sources and maximum allowable concentrations in surface water and drinking water, in line with international agreements such as the Minamata Convention.
Related questions
Monitoring in the EU often finds residues of widely used herbicides and insecticides, including glyphosate and some neonicotinoid insecticides, although most samples stay within legal maximum residue levels.
Some pesticides that act on the nervous system have been linked in studies to lower IQ, attention problems, and other developmental issues in children, especially when exposure occurs during pregnancy or early life.
Organic farming and integrated pest management use alternatives such as beneficial insects, crop rotation, resistant plant varieties, and biological pesticides like bacteria or plant extracts, which can reduce reliance on synthetic chemicals.
Related questions
PFAS have very strong chemical bonds that hardly break down, so they can stay in the environment and in our bodies for many years, and they are used in non‑stick pans, water‑repellent clothing, food packaging, firefighting foams, and many industrial products.
Exposure to some PFAS has been linked to a weaker immune response (for example lower vaccine response), higher cholesterol, liver and thyroid problems, lower birth weight, and an increased risk of some cancers such as kidney and testicular cancer.
PFAS have been measured in European drinking water, in fish and other foods, and in human blood and breast milk, showing that most people in Europe have at least some PFAS in their bodies.
Related questions
Phthalates are used to make soft plastic, so they are often found in vinyl flooring, shower curtains, plastic cables, food packaging, and soft plastic toys, as well as in some cosmetics, perfumes, and personal care products where they help dissolve fragrances.
Phthalates can interfere with our hormone system, and studies link them to reduced fertility, changes in how children grow and develop, and possible effects on metabolism such as increased risk of obesity.
In the EU, several phthalates (DEHP, DBP, BBP, DIBP) are restricted to very low levels (less than 0.1%) in many plastic products, especially toys and childcare items, because of their reproductive and hormone‑disrupting effects.
Arsenic is a chemical element with the symbol As and atomic number 33. It is a metalloid, meaning it has properties that are intermediate between metals and nonmetals. Arsenic is naturally found in the Earth's crust, often in minerals like arsenopyrite, and can also be present in groundwater.
Possible sources of exposure
How Arsenic can enter your body
How Arsenic can enter your body
How Arsenic can enter your body
How Arsenic can enter your body
Arsenic health effects
Reducing your exposure to arsenic
- Avoid smoking as well as inhaling tobacco smoke passively
- If you use a well as a drinking water source, have it tested for arsenic
- Eat a well-balanced diet, alternating the consumption of rice with other grains like millet, quinoa, buckwheat, farro or bulgur. Cooking rice in excess water, which is then drained, can reduce inorganic arsenic content by 40 to 60%, although this also reduces the nutritional content (folate, iron, niacin, thiamine)
- Check the recommendations of your national government or paediatric associations for the nutrition of children. In some countries, young children under five are advised to avoid rice milk as a substitute for breast milk, infant formula or cow’s milk
- Make sure you and your children wash your hands often, especially before eating
The European Union has been taking actions to protect citizens from harmful exposures to arsenic. These include setting maximum levels for arsenic in certain foods and harmonizing requirements for arsenic in drinking water, as well as occupational safety requirements. Arsenic is regulated under EU chemicals legislation and the use of arsenic compounds is restricted under REACH (Registration, Evaluation, Authorisation and Restriction of Chemicals). Arsenic is classified as toxic and carcinogenic under CLP (“Classification, Labelling and Packaging”) Regulation.
For further information on arsenic, please visit the ‘HBM4EU Factsheet’ section.
Related questions
People can be exposed to arsenic through drinking water from contaminated wells, through certain foods like rice and some seafood, and through air or soil near industrial sites or old mining areas.
Long‑term exposure to inorganic arsenic can damage many organs, leading over time to skin changes (such as dark spots or thickened skin), and increasing the risk of cancers of the skin, lungs, and bladder, as well as heart disease and diabetes.
Yes, EU law sets a maximum of 10 micrograms of arsenic per litre in drinking water, and specific maximum levels for inorganic arsenic in foods like rice, rice‑based drinks, salt, and foods for infants and young children.
What the EU is doing to protect citizens from Arsenic?
The European Union has been taking actions to protect citizens from harmful exposures to arsenic. These include setting maximum levels for arsenic in certain foods and harmonizing requirements for arsenic in drinking water, as well as occupational safety requirements. Arsenic is regulated under EU chemicals legislation and the use of arsenic compounds is restricted under REACH (Registration, Evaluation, Authorisation and Restriction of Chemicals). Arsenic is classified as toxic and carcinogenic under CLP (“Classification, Labelling and Packaging”) Regulation.
Bisphenols are a group of chemical compounds commonly used in the production of plastics and resins. They are organic compounds characterized by two hydroxyphenyl groups and are found in products such as polycarbonate plastics and epoxy coatings. Bisphenols can be released into the environment during manufacturing or from consumer products.
Possible sources of exposure
How Bisphenols can enter your body
How Bisphenols can enter your body
How Bisphenols can enter your body
How Bisphenols can enter your body
Bisphenols health effects
Reducing your exposure to bisphenols
- Do not microwave plastic utensils containing Bisphends
- Limit using polycarbonate containers for hot food or drinks
- Do not use damaged plastic food containers
- Avoid infant exposure by choosing BPA-free child products
- Reduce consumption canned food
- Use glass or stainless-steel bottles
- Eat food from metal or ceramic plates
- Use a product only for the intended use
The European Union has taken action to reduce citizen’s exposure to BPA and to prevent regrettable substitution, such as banning BPA from baby bottles across the EY since 1 June 2011 and setting an amount of BPA that is allowed to leach out of toys for children up to the age of three and in any toys that are intended to be placed in a child’s mouth.
For further information on how the European Union is protecting citizens read the HBM4EU Bisphenols Factsheet.
Related questions
BPA is a chemical used to make hard plastics and can linings, and it was banned from baby bottles in the EU because it can mimic hormones and small babies are particularly vulnerable to its possible effects on development.
Bisphenol S (BPS) and bisphenol F (BPF) are often used instead of BPA, but scientific studies show they can also act like hormones, so there is concern that simply swapping BPA for these similar chemicals does not fully solve the problem.
Bisphenols have been linked to possible effects on fertility, changes in thyroid and reproductive hormones, and an increased risk of obesity and some metabolic diseases, although the exact risks at low everyday exposures are still being studied.
What the EU is doing to protect citizens from Bisphenols?
The European Union has taken action to reduce citizen’s exposure to BPA and to prevent regrettable substitution, such as banning BPA from baby bottles across the EY since 1 June 2011 and setting an amount of BPA that is allowed to leach out of toys for children up to the age of three and in any toys that are intended to be placed in a child’s mouth.
Mercury is a chemical element with the symbol Hg and atomic number 80. It is a heavy metal that is liquid at room temperature and occurs naturally in the Earth’s crust. Mercury can be found in air, water, and soil, often as a result of natural processes or industrial activities.
Possible sources of exposure
How Mercury can enter your body
How Mercury can enter your body
How Mercury can enter your body
How Mercury can enter your body
Mercury health effects
Reducing your exposure to mercury
- Avoid using cosmetic products containing mercury
- Avoid heating alloys containing mercury
- Reduce the frequency of consuming large predatory fish and focus on smaller species of fish to maintain a healthy diet; be particularly prudent if pregnant or breastfeeding
- Be careful when handling products containing mercury (fluorescent lamps, old thermometers…) and dispose of them accordingly when damaged - wrapped in plastic and bring it to the local hazardous waste management center
- Ask your dentist about the alternatives for amalgam dental fillings
- Reduce occupational exposure by using protective gear
There are several policies in the European Union for protecting citizens from harmful exposure to mercury such as banning its use in industrial processes, products of daily use and in cosmetics. Moreover, there are legal limits for occupational exposure, mercury presence in fish and regulating mercury use in dentistry and lighting products.
For further information on mercury, please visit the ‘HBM4EU Factsheet’ section.
Related questions
Health agencies in Europe advise most adults to eat fish regularly but to limit large predatory species like shark, swordfish, and some big tuna, and recommend that pregnant women and young children choose smaller, low‑mercury fish such as salmon, sardines, and herring.
Dental amalgam fillings contain mercury, but for most people the small amounts of mercury vapour released are considered low risk; however, the EU is phasing out dental amalgam to reduce overall mercury pollution.
The EU has strict limits on mercury emissions to air from industrial sources and maximum allowable concentrations in surface water and drinking water, in line with international agreements such as the Minamata Convention.
What the EU is doing to protect citizens from Mercury?
There are several policies in the European Union for protecting citizens from harmful exposure to mercury such as banning its use in industrial processes, products of daily use and in cosmetics. Moreover, there are legal limits for occupational exposure, mercury presence in fish and regulating mercury use in dentistry and lighting products.
Pyrethroids
Organophosphates
Glyphosate & AMPA
Pesticides are chemical substances used to prevent, destroy, or control pests such as insects, weeds, and fungi. They include a wide range of compounds with different chemical properties and applications in agriculture, public health, and industry. Pesticides can enter the environment through application to crops, soil, and water.
Possible sources of exposure
How Pesticides can enter your body
How Pesticides can enter your body
How Pesticides can enter your body
How Pesticides can enter your body
Pesticides health effects
Reducing your exposure to pesticides
- Never remove labels from products
- Consider choosing organic food
- Consider consuming European commodities, as pesticide residues are often higher in products produced outside the EU and they can also contain pesticides that are not allowed for use in the EU
- Rinse fruits and vegetables before consuming them, remove the skin or outer leaves and wash your hands after touching unwashed fruits and vegetables
- Use pesticide-free methods for pest prevention in your home and garden
- Prefer to use a physical barrier for avoiding mosquitoes
- To help control fleas without pesticides, comb pets with a flea comb, regularly bath pets with pesticide-free shampoo, and wash pet bedding
If you apply pesticides:
- Read and follow the label instructions for use, storage, and disposal
- Wear protective clothing and equipment
- Always keep children and pets away
- After you are done, wash your hands, face, and clothing
There are several policies in the European Union for protecting the public, workers and the environment from harmful exposures to pesticides such as restricting the use of certain pesticide active substances based on their level of toxicity. Other are related to setting maximum limits for pesticide residues in food, infant formulae, water for public consumption and in animal feed. The “Farm to Fork Strategy” sets an ambitious goal of pesticides by 50% and to reduce by at least 20% the use of fertilizers by 2030.
For further information on pesticides, please visit the ‘HBM4EU Factsheet’ section.
Related questions
Monitoring in the EU often finds residues of widely used herbicides and insecticides, including glyphosate and some neonicotinoid insecticides, although most samples stay within legal maximum residue levels.
Some pesticides that act on the nervous system have been linked in studies to lower IQ, attention problems, and other developmental issues in children, especially when exposure occurs during pregnancy or early life.
Organic farming and integrated pest management use alternatives such as beneficial insects, crop rotation, resistant plant varieties, and biological pesticides like bacteria or plant extracts, which can reduce reliance on synthetic chemicals.
What the EU is doing to protect citizens from Pesticides?
There are several policies in the European Union for protecting the public, workers and the environment from harmful exposures to pesticides such as restricting the use of certain pesticide active substances based on their level of toxicity. Other are related to setting maximum limits for pesticide residues in food, infant formulae, water for public consumption and in animal feed. The “Farm to Fork Strategy” sets an ambitious goal of pesticides by 50% and to reduce by at least 20% the use of fertilizers by 2030.
PFAS are a large family of man-made chemicals, often called "forever chemicals," that resist heat, grease, oil, and water and have been used since the 1940s in many products like non-stick cookware, stain-resistant fabrics, and firefighting foams. Because they break down very slowly, they are persistent in the environment and can accumulate in the human body, potentially leading to health issues like immune system effects, thyroid issues, and an increased risk of certain cancers. Exposure can occur through contaminated water, food, dust, and consumer products.
Possible sources of exposure
How PFASs can enter your body
How PFASs can enter your body
How PFASs can enter your body
How PFASs can enter your body
PFASs health effects
Reducing your exposure to PFAS
- Avoid fast-food wrapped in grease-proof papper.
- Avoid fast-food sold in PFAS-containing cardboard, such as pizza boxes.
- Avoid using optional waterproofing sprays on clothing and footwear.
- Ask for PFAS-free products when purchasing products that my contain PFAS. Ensure that products are free all PFAS (and not just PFOS and PFOA).
- Check whether a particular product contains PFAS or not in online applications.
If you live in or near areas known to be contaminated by PFAS
- Avoid fishing and consuming fish from these areas.
- Avoid consuming home-grown fruits and vegetables from these areas.
- Ask local authorities to assess the PFAS levels to reassure yourself that it is free of PFAS.
- Please follow the advice from authorities for water use.
The EU has taken action to reduce people's exposure to PFAS. For example, PFOS, its salts and derivatives as well as PFOA, its salts and PFOA-related compounds are banned under the Regulation on Persistent Organic Pollutants. The European Food Safety Authority has defined a limit for the volume of four PFAS that may be safely consumed in food in a one-week period. EU REACH restrictions are also adopted for PFHXS en C9-C14 PFAS and will be effective in the coming years for several uses. Also, the Drinking Water Directive sets limit values for PFAS in water for human consumption. Most recently, the Chemicals Strategy for Sustainability set out a range of actions to regulate PFAS as a group, including phasing out the use of PFAS in the EU, unless their use is essential.
For further information on how the European Union is protecting citizens read the “What EU does”, or read here for more information on “What PARC” does on PFAS.
Related questions
PFAS have very strong chemical bonds that hardly break down, so they can stay in the environment and in our bodies for many years, and they are used in non‑stick pans, water‑repellent clothing, food packaging, firefighting foams, and many industrial products.
Exposure to some PFAS has been linked to a weaker immune response (for example lower vaccine response), higher cholesterol, liver and thyroid problems, lower birth weight, and an increased risk of some cancers such as kidney and testicular cancer.
PFAS have been measured in European drinking water, in fish and other foods, and in human blood and breast milk, showing that most people in Europe have at least some PFAS in their bodies.
What the EU is doing to protect citizens from PFASs?
The EU has taken action to reduce people's exposure to PFAS. For example, PFOS, its salts and derivatives as well as PFOA, its salts and PFOA-related compounds are banned under the Regulation on Persistent Organic Pollutants. The European Food Safety Authority has defined a limit for the volume of four PFAS that may be safely consumed in food in a one-week period. EU REACH restrictions are also adopted for PFHXS en C9-C14 PFAS and will be effective in the coming years for several uses. Also, the Drinking Water Directive sets limit values for PFAS in water for human consumption. Most recently, the Chemicals Strategy for Sustainability set out a range of actions to regulate PFAS as a group, including phasing out the use of PFAS in the EU, unless their use is essential.
Phthalates are a class group of chemicals mainly used as plasticisers to make increase the flexibility and durability of plastics softer and more flexible. They are widely used in consumer products and can also be found in personal care products. They are esters of phthalic acid and are commonly found in products such as vinyl plastics, personal care items, childcare products, and packaging materials. Phthalates do not chemically bind to products and can be released into the environment from consumer products over time. Some phthalates are known to disrupt the endocrine system and may affect human health.
Possible sources of exposure
How Phthalates & Substitutes can enter your body
How Phthalates & Substitutes can enter your body
How Phthalates & Substitutes can enter your body
How Phthalates & Substitutes can enter your body
Phthalates & Substitutes health effects
HBM4EU studies found that some European children and adolescents exceeded health-based guidance values for certain phthalates, and combined exposure to mixtures remains a concern.
Reducing your exposure to phthalates
- Avoid heating food in plastic containers
- Prefer glass, stainless steel, or ceramic food containers
- Ventilate indoor spaces regularly
- Reduce indoor dust by cleaning frequently
- Choose phthalate-free cosmetics and personal care products when possible
- Limit the use of soft plastic products for children
- Wash hands regularly, especially before eating
- Follow safety guidance when handling industrial products
EU Action
The European Union has introduced regulatory measures aimed at reducing human exposure to phthalates and their alternatives:
- Phthalates are regulated through a comprehensive chemicals safety framework that controls their manufacture, import, and use, with particularly strict oversight for substances associated with health risks.
- Some phthalates with hazardous properties (e.g., effects on reproduction and/or hormone systems) are identified as substances of high concern such as DEHP, DCHP, DiBP, DnBP, DnPEP, BBzP and DnHexP
- Their use is further restricted in certain consumer products, especially items intended for children, where only very low levels are permitted or their use is not allowed in order to reduce potential health risks, including exposure from substances such as DEHP, DnBP, BBzP, and DiNP.
- Certain phthalates classified as reproductive toxicants are restricted in consumer products, with strict limits on their concentration (e.g., in plastics and consumer goods), meaning substances such as DEHP, DnBP, BBzP, and related compounds are only allowed at very low levels or not at all in products for the general public due to potential health risks.
- The EU uses a prioritisation process to evaluate chemicals of potential concern and assess whether further regulatory action is needed including DPHP, DCHP, DEP and DEHA.
- EU rules for food contact materials restrict certain hazardous phthalates (e.g., DEHP, DnBP, BBzP, DiBP, DiNP, DiDP, DEHA, DEHT, DINCH) in food packaging and related applications, setting strict limits on how much can migrate into food, both individually and in combination, to reduce consumer exposure from packaging materials.
- Cosmetic products are subject to strict safety rules that prohibit certain phthalates (e.g., DEHP, DnBP, BBzP, DiBP) due to health concerns from dermal exposure.
- Medical devices are regulated under a framework that allows the use of certain phthalates (e.g., DEHP, DnBP, BBzP, DiBP) when their use is justified, despite potential health concerns such as reproductive toxicity or endocrine-disrupting effects, while requiring manufacturers to assess risks and consider safer alternatives.
- Electrical and electronic equipment is subject to restrictions on hazardous substances, including certain phthalates (e.g., DEHP, DnBP, BBzP, DiBP), to reduce health and environmental risks and encourage safer alternatives, with limited exemptions.
Related questions
Phthalates are used to make soft plastic, so they are often found in vinyl flooring, shower curtains, plastic cables, food packaging, and soft plastic toys, as well as in some cosmetics, perfumes, and personal care products where they help dissolve fragrances.
Phthalates can interfere with our hormone system, and studies link them to reduced fertility, changes in how children grow and develop, and possible effects on metabolism such as increased risk of obesity.
In the EU, several phthalates (DEHP, DBP, BBP, DIBP) are restricted to very low levels (less than 0.1%) in many plastic products, especially toys and childcare items, because of their reproductive and hormone‑disrupting effects.
What the EU is doing to protect citizens from Phthalates?
- EU chemicals governance (REACH Regulation (EC) No 1907/2006) provides the core framework for the control of phthalates across manufacture, import, and use under ECHA oversight. Substances may be identified as Substances of Very High Concern (SVHCs) under REACH Article 57, including those with CMR and endocrine-disrupting properties, and may subsequently be placed under authorisation requirements (Annex XIV).
- Use restrictions under REACH Annex XVII impose binding limits on hazardous phthalates in consumer and industrial products, including a general threshold of 0.1% (w/w) for substances such as DEHP, DnBP, BBzP, and DiBP, with additional targeted restrictions for toys and childcare articles (e.g. DiNP, DiDP, DnOP). These measures are complemented by hazard-based classification under the CLP Regulation (EC) No 1272/2008 (Annex VI), which harmonizes CMR classifications across the EU.
- Cross-cutting consumer safety enforcement is strengthened by the General Product Safety Regulation (EU) 2023/988, under which products containing hazardous substances may be deemed unsafe if exposure risks cannot be adequately controlled.
- Scientific risk assessment and regulatory prioritisation is supported through REACH processes such as CoRAP (Community Rolling Action Plan), which identifies substances for multi-year evaluation. While major legacy phthalates (e.g. DEHP, DnBP, BBzP, DiBP) are largely addressed through existing restrictions, a limited number of remaining phthalates and structural substitutes (e.g. DCHP, DPHP, DEP, DEHA) continue to be assessed for potential risks such as endocrine disruption, CMR properties, and wide dispersive use.
- Scientific committee support (ECHA RAC and SEAC) under the REACH Annex XV restriction process has confirmed that EU-wide restrictions on key phthalates (DEHP, DnBP, BBzP, DiBP) are scientifically justified due to reproductive toxicity and overall risk, and that such measures are proportionate and effective while allowing limited derogations for specific applications.
- EU food contact materials (FCM) legislation restricts the use of hazardous phthalates in food packaging applications under Regulation (EC) No 450/2009 and Commission Regulation (EU) No 10/2011, which together govern the safety of plastic food contact materials.
- The framework sets specific migration limits (SMLs) and cumulative exposure limits (SML(T)) for phthalates such as DEHP, DnBP, BBzP, DiBP, DiNP, and DiDP, applying both individual and group-based restrictions (Groups 26, 32, and 36) to control combined exposure from multiple sources.
- More recent updates under Commission Regulation (EU) 2023/1442 further tighten migration limits and exposure assessment requirements, strengthening risk control for phthalates in food contact applications.
- EU cosmetics regulation under Regulation (EC) No 1223/2009 establishes a harmonised safety framework for cosmetic products, including the prohibition of specific phthalates in Annex II (e.g. DEHP, DnBP, BBzP, DiBP), while some alternative plasticisers such as DEP, DMP, DINCH, and DEHT are not restricted.
- The current framework consolidates and standardises earlier national restrictions under the former Council Directive (76/768/EEC) to cosmetic products, ensuring uniform safety requirements across all Member States and full applicability since 2013.
- EU medical device regulation under Regulation (EU) 2017/745 sets a harmonised framework for the safety of medical devices, allowing the use of certain phthalates (e.g. DEHP, DnBP, BBzP, DiBP and related compounds) only when scientifically justified, particularly where no suitable alternatives exist.
- The framework requires manufacturers to perform risk assessments, regularly review scientific evidence, and justify the use of such substances, while encouraging substitution with safer alternatives where feasible.
- For in vitro diagnostic medical devices, Regulation (EU) 2017/746 similarly, highlights hazardous phthalates and related substances as relevant safety concerns requiring risk assessment and regulatory control.
- EU RoHS Directive (2011/65/EU, amended by (EU) 2015/863) restricts hazardous substances in electrical and electronic equipment (EEE), including phthalates such as DEHP, DnBP, BBzP, and DiBP, to reduce health and environmental risks and promote safer alternatives.
- The regulation applies broadly across EEE, with limited exemptions and phased implementation of phthalate restrictions across additional product categories since 2021.
What PARC does on phthalates and non-phthalate substitutes
PARC builds on HBM4EU to harmonise human biomonitoring (HBM) across Europe, generating comparable data on exposure to phthalates and their alternatives in the general and occupational population. Biomarkers of these substances are analysed in human matrices (urine, blood, hair) from children, adolescents, and adults across Europe to capture aggregate exposure from all sources and pathways. It integrates bio-monitoring, analytical method development, and quality assurance to assess exposure levels and associated health effects.
Research focuses on aggregate exposure from multiple sources and pathways, evaluates temporal trends, identifies exposure determinants, and investigates expo-sure-effect relationships, including developmental outcomes such as neurodevelop-ment following prenatal exposure.
PARC further advances the derivation of HBM guidance values (HBM-GVs) and indoor air guideline values (IA-GVs), supports the development of new biomarkers (e.g. DnHexP secondary metabolites), and strengthens the integration of effect biomarkers and health outcomes into aligned studies.
Key Activities
- Harmonising HBM methods, QA/QC systems, and data handling for phthalates and alternatives
- Conducting EU-wide population and targeted occupational studies (e.g. waste and plastic recycling)
- Developing and validating analytical methods for phthalate metabolites and substitutes
- Investigating exposure pathways, determinants, and time trends
- Linking biomonitoring data with effect biomarkers and health outcomes
- Supporting regulatory use through guidance values and data platforms (EU HBM Dashboard)
Environmental monitoring focuses on endocrine-disrupting chemicals, including phthalates and non-phthalate plasticisers, with particular attention to non-food expo-sure media. The aim is to assess how environmental compartments, consumer pro-ducts, and diet contribute to internal exposure levels. Activities include multisource exposure assessment and the development of harmonised monitoring frameworks for long-term application, including indoor environments to better understand exposure situations relevant for vulnerable groups such as children.
Innovative analytical approaches using non-targeted chemical profiling are applied to human, environmental, and food samples to characterise complex real-life co-expo-sures. These methods enable the detection of multiple exposure markers, including phthalate-related compounds and metabolites. In combination with effect biomarkers, these approaches support the identification of exposure patterns and mixtures and strengthen causal analyses and modern epidemiological approaches in future HBM studies.
Key Activities
- Identifying hazardous substances leaching from plastic materials using NAM-based toxicity testing and non-targeted screening
- Developing integrated, tiered testing strategies combining omics technologies, in vitro and in silico methods for hazard characterisation
- Investigating endocrine, metabolic, and immunological effects of phthalates and their alternatives
- Advancing methods for mixture assessment and chemical grouping approaches
- Developing and applying AOP frameworks to support mechanistic understanding of toxicity
- Improving PBK/PBTK modelling, including ADME processes, human variability, and life-stage-specific kinetics
- Supporting quantitative in vitro-in vivo extrapolation (QIVIVE) and regulatory application of NGRA approaches
PARC advances hazard assessment for human health and the environment by addressing data gaps for phthalates and their alternatives, and by developing and applying innovative methodologies in support of Next Generation Risk Assessment (NGRA). The work integrates new approach methodologies, mechanistic understanding via adverse outcome pathways (AOPs), and modelling approaches such as physio-logically based toxicokinetic (PBTK) modelling to improve the assessment of endocrine, metabolic, and immunological effects.
Research includes the identification of hazardous substances released from plastic materials, the application of targeted and non-targeted testing strategies, and the development of predictive tools for single substances and mixtures. A strong focus is placed on linking experimental data with mechanistic frameworks and quantitative models to support regulatory decision-making.
PARC supports the advancement of regulatory risk assessment by developing inte-grated and innovative approaches for assessing risks of phthalates and their alterna-tives across multiple exposure sources, pathways, and regulatory sectors. The work combines exposure modelling, human biomonitoring (HBM), PBK modelling, and mechanistic frameworks (AOPs, IATAs) to better capture realistic lifetime exposures and associated health effects, including reproductive, developmental, immunological, and neurological outcomes.
Research focuses on linking external exposure sources (e.g. indoor environments, consumer products) to internal doses, assessing aggregate and mixture exposures, and improving the consistency and applicability of risk assessment methodologies across regulatory frameworks. It also evaluates current regulatory approaches for plasticisers and develops tools to support harmonised, science-based decision-making.
Key Activities
- Developing integrated source-to-dose and aggregate exposure models for phthalates across environments and pathways
- Combining HBM data and PBK modelling to identify major exposure sources and risk drivers
- Assessing real-life mixtures of phthalates with a focus on reproductive toxicity
- Advancing burden of disease (BoD) approaches for phthalate-related health outcomes
- Evaluating and comparing regulatory risk assessment approaches for plasticisers across EU frameworks
- Developing and testing methods for mixture risk assessment
- Improving tools and data systems for regulatory use (e.g. PARC Toolbox, data-bases, screening methods)
- Supporting enforcement through innovative analytical and data-driven approaches for detecting regulated substances in products
PARC develops concept and toolbox approaches to improve the early identification and prioritisation of phthalates as hazardous endocrine-disrupting chemicals. Since phthalates show anti-androgenic and estrogenic activity, they are relevant targets for early warning systems that combine effect-based monitoring and effect-directed analysis.
In parallel, PARC is expanding its integrative modelling platform to support advanced expo-sure and risk assessment. This includes the further development of models for phthalates, improved exposure reconstruction, probabilistic simulations, and the integration of environ-mental, dietary, and internal dose information with in silico and new approach methods.
Why PARC’s work matters
Research shows that phthalates and their alternatives are widespread in the environment and detectable in the human body. However, important knowledge gaps remain regarding aggregate exposure from multiple sources, long-term health effects, mixture toxicity, and harmonised approaches for monitoring and risk assessment.
PARC helps address these challenges by:
- Building harmonised European human biomonitoring (and environmental moni-toring) systems for phthalates and alternative plasticisers
- Improving analytical methods, quality assurance systems, and innovative tools for detecting exposure markers and hazardous substances
- Supporting evidence-based risk assessment and regulation through guidance values, exposure modelling, and NGRA approaches
- Connecting human health, environmental monitoring, and mechanistic toxicology through integrated One Health and source-to-dose approaches
- Advancing research on endocrine, reproductive, developmental, metabolic, immuno-logical, and neurological effects linked to phthalate exposure
- Creating collaboration between research institutes, regulators, and stakeholders across Europe to harmonise data, methods, and regulatory tools
- PARC’s work contributes to safer chemicals management, improved understanding of phthalate-related risks, and the development of more effective strategies to reduce harmful exposures across Europe.
Findings within PARC
- PARC Aligned Studies harmonise HBM surveys across Europe to generate comparable data on chemical exposure (e.g. phthalates, bisphenols, PFAS) in children, teenagers, and adults, supporting EU-wide exposure assessment and policy evaluation.
- Elevated MnHexP levels in HBM data from Germany and Denmark triggered PARC’s Rapid Response Mechanism in 2024. Current evidence identifies contamination of the UV filter DHHB with DnHexP as the most likely exposure source.
- HBM-GVs for DiNP and DEHTP were derived to enable the interpretation and health-based assessment of HBM measurements.
- HBM data generated within HBM4EU were analyzed for phthalates and DINCH to investigate exposure-health outcome associations and to explore causal pathways, including effect markers as potential mediators.
- Novel in vitro and metabolomics-based approaches advanced the assessment of phthalates and substitutes, including evidence for DINCH and MINCH as metabolism-disrupting chemicals.