PARC successfully delivered the remote course on TKPlate, EFSA ↗’s open-access platform for toxicokinetic (TK) and toxicodynamic (TD) modelling. The 3.5-hour online training was coordinated by Jean-Lou Dorne (European Food Safety Authority ↗) and Keyvin Darney (ANSES ↗), both part of the team that developed the TKPlate platform. The course provided background on new approach methodologies (NAMs), physiological-based kinetic (PBK) models in human and animal health risk assessment, and toxicokinetic–toxicodynamic (TKTD) models in ecological risk assessment. It then covered the seven modules of the platform, its future development, and case studies demonstrating its practical use for next-generation risk assessment (NGRA).

The course, helded on 9 December 2025, attracted 137 participants, reflecting strong interest from both PARC partners (who represented 59.1% of attendees, spanning multiple work packages, particularly WP5 and WP6) and the wider scientific and regulatory community. Participants represented a broad range of institutions, including academia (32.1%), business and industry (21.2%), government authorities (20.4%), R&D organisations (14.6%), and regulatory bodies (9.5%).

Attendees came from 26 countries, with the largest representations from Germany (17.5%), Italy (10.9%), Belgium and Spain (both 9.5%), and Switzerland (6.6%), highlighting the course’s wide international reach. From a professional perspective, most participants worked in toxicology (81.8%) and risk/health impact assessment (61.3%), with additional expertise in data science, environmental health, and public health.

One of the participants noted:

“As the TK Plate tool might play a more substantial role in the close future, attending the course was a natural choice for me. The course was very informative, well executed, and planned in a thoughtful way. That was a great opportunity to refresh knowledge regarding ADME and get a glimpse into the tools of tomorrow”.

Overall, the programme combined theoretical foundations with practical demonstrations of TKPlate workflows, illustrating how NAMs can be integrated into NGRA. By strengthening participants’ practical understanding of TKTD modelling and its regulatory relevance, the training directly supported PARC’s objectives of promoting the uptake of innovative, science-based tools, fostering harmonised risk-assessment practices across Europe, and building capacity among both researchers and risk assessors. Overall, the course strengthened European capacity to apply TKTD modelling in regulatory chemical risk assessment, in line with PARC’s strategic goals.

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