Key messages The current regulatory uptake of New Approach Methodologies ( NAMs) and NAM-based approaches for hazard and risk assessment of chemical substances is limited. By conducting case studies addressing specific problem formulations for certain health effects and regulatory contexts we aim to highlight both opportunities and challenges related to...

Overview The European Chemicals Agency ( ECHA) is incorporating international guidelines like the revised OECD Guidance Document 150 into its regulatory processes for evaluating biocides and pesticides for potential endocrine-disrupting effects. However, current testing methods and regulations still fall short when it comes to identifying substances that interfere with the...

Key messages Current biomonitoring methods are limited in assessing the full spectrum of chemical exposures, especially with emerging chemicals in occupational sectors. Innovative screening methods (SS/NTS) and new sampling tools (DBS, SWB) offer a promising alternative to traditional approaches, enabling more comprehensive exposure assessment. The project will demonstrate the proof...

Overview Enhancing the transparency and acceptance of artificial intelligence (AI) and machine learning (ML) techniques in chemical risk assessment is the focus of this initiative. With an increasing reliance on these advanced methods for predicting chemical behaviour and assessing risks, addressing the challenges posed by unclear documentation and limited access...