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News

PARC training - in silico models and read across

Empowering the risk assessment community: PARC’s in silico models and read-across training

On 3-4 March 2025, PARC hosted the remote training course " Use and interpretation of the results of in silico models and read-across", aimed at strengthening expertise in predictive toxicology. This training was coordinated by Istituto Mario Negri (IRFMN), Italy, under the scientific leadership of Emilio Benfenati, and provided participants...

Training - In silico models and read-across

PARC is organising a training course on in silico models and read-across

PARC is organising a remote training course on the use and interpretation of in silico models and read-across, with a special focus on VEGAHUB and applications related to human, ecotoxicological, and environmental properties. The online course will take place on 3-4 March 2025. The scientific coordination is provided by the...

Online survey - artificial intelligence, machine learning

Do you have any opinion on the use of computational new approach methodologies in regulatory applications?

The use of artificial intelligence (AI) and machine learning (ML) has revolutionized the world in recent years. Within PARC, a survey has been launched on landscape and readiness of computational new approach methodologies based on ML and AI approaches for next generation risk assessment of chemicals. This survey examines whether...

SYNnet first synergies

PARC established the first four official synergies

To further support its mission, PARC has established SYNnet, a network designed to facilitate collaboration and knowledge sharing with other initiatives, projects, organisations. Since its inception, SYNnet has made substantial progress in fostering synergies and collaborations. An agreement was signed with the Joint Research Centre (JRC), and the process to...

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Events

In silico models and read-across

PARC is organising a remote training course on the use and interpretation of in silico models and read-across, with a special focus on VEGAHUB and applications related to human, ecotoxicological, and environmental properties. The online course will take place on 3-4 March 2025. The scientific coordination is provided by the...

2 results

Thematic areas

Building infrastructure and human capacities:

Harmonised QA/QC in laboratory testing

Check out how we work towards increased harmonisation of quality assurance (QA) and quality control (QC) in chemical analysis and toxicity testing to ensure that monitoring and hazard data generated in PARC are reliable, consistent, and comparable.

Risk assessments:

Hazard assessment

Learn new approaches and methods of health assessment and provide data to fill gaps in knowledge on poorly characterised contaminants or new emerging hazards while promoting the use of innovative methods.

2 results

Projects

Developing and testing new approaches for chemical exposure assessment of infants

Key messages Assessing chemical exposure at early stage of life is still a challenge. Today, new tools are available that enhance chemical exposure assessment. Efforts are ongoing to refine and clarify the applicability and effectiveness of these approaches. Their value in chemical prioritisation and contribution to early warning systems has...

Improving testing methods for thyroid hormone disrupting chemicals

Overview The European Chemicals Agency ( ECHA) is incorporating international guidelines like the revised OECD Guidance Document 150 into its regulatory processes for evaluating biocides and pesticides for potential endocrine-disrupting effects. However, current testing methods and regulations still fall short when it comes to identifying substances that interfere with the...

8 results

Publications

Ecotoxicological Evaluation of Bisphenol A and Alternatives: A Comprehensive In Silico Modelling Approach

Ecotoxicological evaluation of Bisphenol A and alternatives: A comprehensive in silico modelling approach

Bisphenol A (BPA), a compound widely used in industrial applications, has raised concerns due to its environmental impact. As a key component in the manufacture of polycarbonate plastics and epoxy resins used in many consumer products, concerns about potential harm to human health and the environment are unavoidable. This study...

Intuitive toxicology in the 21st century - Bridging the perspectives of the public and risk assessors in Europe

Intuitive toxicology in the 21st century—Bridging the perspectives of the public and risk assessors in Europe

Three decades ago, several articles on the subjectivity in chemical risk judgments (i.e., labeled “intuitive toxicology”) measured the divide between the public and toxicologists with different backgrounds regarding the validity of predicting health effects based on in vivo studies. Similar divides with impacts on societal discourse and chemical risk assessment...

Cover_Pharmacophore Modeling Using Machine Learning forScreening the Blood–Brain Barrier Permeation of Xenobiotics

Pharmacophore modeling using machine learning for screening the blood–brain barrier permeation of xenobiotics

Daily exposure to xenobiotics affects human health, especially the nervous system, causing neurodegenerative diseases. The nervous system is protected by tight junctions present at the blood–brain barrier (BBB), but only molecules with desirable physicochemical properties can permeate it. This is why permeation is a decisive step in avoiding unwanted brain...

Acetylcholinesterase inhibition in rats and humans following acute fenitrothion exposure predicted by physiologically based kinetic modeling-facilitated quantitative in vitroto in vivo extrapolation

Acetylcholinesterase inhibition in rats and humans following acute fenitrothion exposure predicted by physiologically based kinetic modeling-facilitated quantitative in vitro to in vivo extrapolation

Worldwide use of organophosphate pesticides as agricultural chemicals aims to maintain a stable food supply, while their toxicity remains a major public health concern. A common mechanism of acute neurotoxicity following organophosphate pesticide exposure is the inhibition of acetylcholinesterase (AChE). To support Next Generation Risk Assessment for public health upon...

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Learning materials

Improving Mixtures Health Assessments: Combining In Silico with In Vitro / In Vivo Models to Evaluate Co-occurring Contaminant

Methods to evaluate exposure to combined exposures and chemical mixtures, including computer models