Search | Parc

197 results

News

Successful PARC Modelers’ meeting in Tartu strengthens collaboration

A productive meeting in Tartu, Estonia, brought together modelers from across PARC to share progresses, exchange ideas, and build new collaborations. The PARC Modelers' Meeting, held from June 9 to 11 2025, was hosted by the Chair of Molecular Technology of the Institute of Chemistry of the University of Tartu...

Launch of Integrative Model Network website marks milestone in chemical risk assessment

PARC has launched a dedicated website for the Integrative Model Network for chemical risk assessment, representing an important step toward supporting the modernisation of chemical risks assessment. Designed as an evolving hub for researchers, regulators, and other stakeholders, the platform provides access to chemical risk assessment workflows integrating data and...

PARC research projects online: greater accessibility and greater impact

In the last issue of Sampler, we shared the first milestone in making PARC's research projects visible and accessible to a broader audience – an effort that received extremely positive feedback from our community and stakeholders. Since then, we have significantly stepped up our efforts. Today, over 60 research projects...

Air laboratory network

PARC expands laboratory maps: updated human biomonitoring map and new air quality lab map launched

The European Partnership for the Assessment of Risks from Chemicals (PARC) is strengthening Europe’s scientific infrastructure with two major updates: an expanded interactive map of human biomonitoring (HBM) laboratories and the launch of a new map showcasing laboratories specialised in air quality analysis across Europe. These interactive tools aim to...

224 results

Events

7th Croatian Congress of Toxicology

7 th International Congress of the Croatian Society of Toxicology (CROTOX 2025) with international participation brings together scientists addressing current challenges, innovations and future directions in toxicology: cellular toxicity and mechanisms of damage, risk assessment and regulatory science, oxidative stress and biomarkers, translational research in toxicology, opportunities and challenges in...

Berlin Neuroscience Meeting 2025

The Berlin Neuroscience Meeting 2025 will take place at the Einstein Center for Neurosciences, and convenes neuroscientists, clinicians, and researchers to explore advances in brain research, neurobiology, and translational neuroscience. The meeting features keynote lectures, thematic sessions, poster presentations, and networking opportunities. Indigo Brakus ( German Federal Institute for Risk...

International Conference on Non-Target Screening

The International Conference on Non-Target Screening will bring together scientists, instrument manufacturers, and software developers to present the latest advances in non-target screening (NTS) techniques and applications. The conference aims to harmonize strategies and workflows across disciplines, promoting methodological innovation, data standardization, and improved reporting practices in NTS. PARC will...

PARC International Board Meeting

The 3rd Quarterly International Board Meeting will convene PARC partners to review progress and plan future activities. The agenda includes updates from key Work Packages on omics-based approaches, biological diversity, data standardization, and policy brief integration. Strategic discussions will focus on the establishment of new working groups in priority areas...

83 results

Projects

Tools, criteria and methods for risk assessment

Key messages At present, risk assessment approaches are not coherent across different regulatory frameworks compromising the consistency of decision making and the achievement of policy objectives. Level of required protection or safety margins for human health and the environment may vary significantly between different frameworks even in similar regulatory contexts...

Streamlining data processing methods for suspect and non-target screening

Improving the environmental risk assessment for plant protection products

Key messages Reach a common understanding of what needs to be improved in the environmental risk assessment for plant protection products, such as the need to: Overcome the limitations of the current substance-by-substance approach, Adopt a more realistic consideration of the environmental context. Address issues related to improving environmental risk...

Benchmarking the environmental risk assessment of plant protection products

Key messages Consistent risk assessment requires that risks of compounds can be compared and ranked Evaluation of current approach and development of concepts and methodologies to improve comparability Risk assessment outcomes should also hold against relative risks of compounds identified in real world studies Overview This project aims to demonstrate...

166 results

Publications

Pioneering an effect-based early warning system for hazardous chemicals in the environment

Pioneering an effect-based early warning system for hazardous chemicals in the environment

Existing regulatory frameworks often prove inadequate in identifying contaminants of emerging concern (CECs) and determining their impacts on biological systems at an early stage. The establishment of Early Warning Systems (EWSs) for CECs is becoming increasingly relevant for policy-making, aiming to proactively detect chemical hazards and implement effective mitigation measures...

Chemical respiratory sensitization

Chemical respiratory sensitization — Current status of mechanistic understanding, knowledge gaps and possible identification methods of sensitizers

Respiratory sensitization is a complex immunological process eventually leading to hypersensitivity following re-exposure to the chemical. A frequent consequence is occupational asthma, which may occur after long latency periods. Although chemical-induced respiratory hypersensitivity has been known for decades, there are currently no comprehensive and validated approaches available for the prospective...

Investigation of peroxisome proliferator-activated receptor genes as requirements for visual startle response hyperactivity in larval zebrafish exposed to structurally similar per- and polyfluoroalkyl substances (PFAS)

Investigation of peroxisome proliferator-activated receptor genes as requirements for visual startle response hyperactivity in larval zebrafish exposed to structurally similar per- and polyfluoroalkyl substances (PFAS)

Background: Per- and polyfluoroalkyl Substances (PFAS) are synthetic chemicals widely detected in humans and the environment. Exposure to perfluorooctanesulfonic acid (PFOS) or perfluorohexanesulfonic acid (PFHxS) was previously shown to cause dark-phase hyperactivity in larval zebrafish. Objectives: The objective of this study was to elucidate the mechanism by which PFOS or...

Cross-mapping of terms used in chemical risk assessment with those used in systematic review: research protocol

Cross-mapping of terms used in chemical risk assessment with those used in systematic review: research protocol

The focus on implementation of systematic review (SR) principles in chemical risk assessments (CRAs) is growing as it has the potential to advance the rigour and transparency of the CRAs. However, the SR and CRA communities use their own specific terminologies. Understanding the meaning of core SR and CRA terms...

78 results

Deliverables

Prioritisation criteria report

Periodic report on available supporting materials for HBM studies

Concept and plan of effect-based monitoring and effect directed analysis (EDA) of chemicals towards EWS

Inventory of existing EBD, HIA, exposure and exposure-effect data for chemicals prioritized in PARC

99 results

Learning materials

Safe and Sustainable by Design chemicals and materials

The session outlines how stakeholder comments have influenced revisions to the proposed framework. It also includes a presentation of the updated framework and key changes introduced.

This video introduces the concept of Safe-by-Design (SbD) and explores its importance in integrating safety into innovation workflows. Learn how SbD anticipates risks in emerging technologies and helps develop sustainable, responsible, and safe innovations.

Nanosafety | NanoLund

Discover insights into nanomaterials' human and environmental toxicology, as well as of emissions and exposure in all stages of the lifecycle of a nanomaterial. This research supports Safe(r)-and-sustainable-by-design approaches in developing and producing novel materials.

Safe Innovation Approach (SIA)

Introduces the Safe Innovation Approach, combining Safe by Design and Regulatory Preparedness to address safety early in the innovation process, with a focus on nanomaterials.

203 results

Partners

Stockholm University

Svante Arrhenius väg 8, 114 18

University of Tartu

Ülikooli 18, 50090

University of Basel

Peterspl. 1, 4001

French National Institute for Industrial Environment and Risks

Parc Technologique ALATA,

Verneuil-en-Halatte

251 results

Laboratories

Masaryk University

Kamenice 753, 625 00 Brno-Bohunice

Technical University of Denmark, National Food Institute (DTU)

Henrik Dams Allé, Building 202, DK-2800 Kgs Lyngby

Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM)

Nikolai-Fuchs-Strasse 1 30625 Hannover

Institute of Health Carlos III (ISCIII)

Ctra. de Pozuelo, 28, 28222 Majadahonda