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News

Training course - NAMs

Highlights from the new approach methodologies and chemical hazard assessment course

What does the future of chemical safety look like? For 38 researchers, regulators, and scientists from around the world, the answer became clearer earlier this month in Brno, Czech Republic. Gathered for an intensive three-day training on new approach methodologies (NAMs) and hazard assessment, they explored cutting-edge tools that are...

Advancing FAIR data for chemical risk assessment: Highlights from the PARC WP7 Annual Meeting

The Annual Meeting of Work Package 7 (WP7) of the European Partnership for the Assessment of Risks from Chemicals (PARC) took place between 11–13 June in Tartu, Estonia. This WP plays a key role in making chemical risk assessment data findable, accessible, interoperable, and reusable, commonly known as FAIR. Hosted...

From data to synergy: Mapping Europe's capacities in chemical hazard research

From data to synergy: Mapping Europe's capacities in chemical hazard research

An important step toward stronger collaboration in chemical hazard assessment has been achieved through an initial mapping of Europe’s research capacities. By collecting insights from over 70 leading experts across 20 countries, the initiative lays the foundation for enhanced cooperation, harmonised methodologies, and shared infrastructures, paving the way for a...

Water laboratories

Join the PARC European Water Laboratory Network

PARC is developing a European Laboratory Network, a collaborative initiative uniting laboratories across Europe with expertise in chemical analysis. This network includes laboratories working in various fields - such as water, air, soil, human biomonitoring, and (eco)toxicological assessments - and aims to foster collaboration, enhance visibility, and offer valuable resources...

224 results

Events

Neuroscience Symposium in Hannover

The ZSN Symposium, organized by the Center for Systems Neuroscience in Hannover, brings together neuroscience researchers from affiliated institutions to promote interaction, scientific exchange, and collaboration. The one-day symposium features scientific talks and poster presentations and serves to inform the membership about ZSN initiatives and future plans. Cody Adams-Niedergeses (...

Advances in Veterinary Pharmacology, Toxicology, and 3R Methods

The 34 th VETPHARM Symposium is a recognized scientific meeting in the field of veterinary pharmacology and toxicology that emphasizes translational and comparative approaches, as well as the development and application of 3R (Replacement, Reduction, Refinement) methods. The symposium brings together researchers, clinicians, veterinarians, and toxicologists to discuss advances in...

Environmental Occurrence, Hazard & Risk of per- and poly-fluoroalkyl substances Symposium

The 4 th EnvironChemTox Symposium on PFAS (per- and poly-fluoroalkyl substances) will focus on the environmental occurrence, fate, exposure, bioaccumulation, and ecotoxicological risks of PFAS. As PFAS continue to draw global attention for their persistence, mobility, and health impacts, this event offers a timely platform for scientists, regulators, and industry...

Interdisciplinary Toxicology Conference

TOXCON 2025 is the International Interdisciplinary Toxicology Conference, continuing the tradition of toxicological symposia organized under the Slovak and Czech toxicology societies. The conference provides a venue for researchers, regulators, and stakeholders to exchange knowledge, present new findings, and discuss challenges in toxicology across multiple domains. Event highlights include: Pre-conference...

83 results

Projects

Tracking emerging chemicals in animal species: A new monitoring approach

Key messages This project will explore the potential of animal species, in particular gammarids and bees, as sentinels of the chemical status of the environment and the human food chain, using innovative screening methods based on advanced high-resolution mass spectrometry and effect-directed analysis. Overview Capturing the complexity of real-world chemical...

Rethinking genotoxicity testing: A non-animal approach

Overview Ensuring chemicals safety for human health and the environment requires reliable testing methods. However, traditional genotoxicity assessments - used to determine whether a substance can damage DNA - often rely on animal testing and fail to incorporate modern scientific advancements. The project is leading the way in developing Integrated...

Roadmap linking chemical substances and health

Key messages The project develops a strategy to connect chemical exposures with health outcomes using effect biomarkers. It follows a two-step approach: integrating health data into human biomonitoring (HBM) surveys and assessing retrospective exposure through biobanked samples. It will deliver concrete tools for PARC surveys, including standardized procedures and materials...

Harmonisation of the risk assessment of chemicals

Key messages Further analysis will focus on assessment processes for specific hazard criteria across frameworks; theoretical analysis of the legal texts and guidance documents to investigate the data requirements and assessment processes. Case studies will be performed on specific substances to analyse what information was required to classify a substance...

166 results

Publications

Automated liquid handling extraction and rapid quantification of underivatized amino acids and tryptophan metabolites from human serum and plasma using dual-column U(H)PLC-MRM-MS and its application to prostate cancer study

Automated liquid handling extraction and rapid quantification of underivatized amino acids and tryptophan metabolites from human serum and plasma using dual-column U(H)PLC-MRM-MS and its application to prostate cancer study

Amino acids (AAs) and their metabolites are important building blocks, energy sources, and signaling molecules associated with various pathological phenotypes. The quantification of AA and tryptophan (TRP) metabolites in human serum and plasma is therefore of great diagnostic interest. Therefore, robust, reproducible sample extraction and processing workflows as well as...

Method optimization for a simultaneous determination of neonicotinoid, carbamate/thiocarbamate, triazole, organophosphate and pyrethroid pesticides and their metabolites in urine using UPLC-MS/MS

Method optimization for a simultaneous determination of neonicotinoid, carbamate/thiocarbamate, triazole, organophosphate and pyrethroid pesticides and their metabolites in urine using UPLC-MS/MS

An accurate and sensitive method for the determination of a total of 23 pesticides and their metabolites in human urine has been optimised. The methodology is based on a previously published method based on solid-phase extraction with methanol and acetone followed by ultra-performance liquid chromatography coupled to tandem mass spectrometry...

Effects of metabolic disruption on lipid metabolism and yolk retention in zebrafish embryos

Effects of metabolic disruption on lipid metabolism and yolk retention in zebrafish embryos

A subgroup of endocrine-disrupting chemicals have the ability to disrupt metabolism. These metabolism-disrupting chemicals (MDCs) can end up in aquatic environments and lead to adverse outcomes in fish. Although molecular and physiological effects of MDCs have been studied in adult fish, few studies have investigated the consequences of metabolic disruption...

Machine learning-based prediction of fish acute mortality: implementation, interpretation, and regulatory relevance

Machine learning-based prediction of fish acute mortality: Implementation, interpretation, and regulatory relevance

Regulation of chemicals requires knowledge of their toxicological effects on a large number of species, which has traditionally been acquired through in vivo testing. The recent effort to find alternatives based on machine learning, however, has not focused on guaranteeing transparency, comparability and reproducibility, which makes it difficult to assess...

78 results

Deliverables

List of prioritized BPA alternatives for WP5 Hazard Assessment activites - Workshop report

PARC governance process timeline

PARCopedia scoping document

99 results

Learning materials

HHEAR Exposomics webinar series

Webinar series on exposomics, a growing field studying lifelong exposures and health.

Rapid assessment of contaminant exposure (RACE) tool

Presents the RACE tool, supporting exposure assessment for food contaminants by comparing intake estimates with health-based guidance values.

The use of artificial intelligence in toxicology

Introduces the fundamentals of deep learning and its application in toxicology, with a focus on model construction, input data handling, and potential uses such as QSAR enhancement.

QSARs and their assessment under dossier evaluation

Covers REACH requirements for QSAR-based adaptations, ECHA’s evaluation approach, and typical deficiencies identified in submitted QSAR studies.

203 results

Partners

Institute of Health Carlos III

Carretera de Majadahonda - Pozuelo, Km. 2.200, 28220 - Majadahonda

National Food Institute, Danish Technical University

Anker Engelunds Vej 411, 2800 Kongens

State Secretariat for Economic Affairs

Holzikofenweg 36, 3003

Scientific and technical center for building

24 Rue Joseph Fourier, 38400

Saint-Martin-d'Hères

251 results

Laboratories

University of Aveiro

Building 3, 5th floor, Santiago University Campus, University of Aveiro, 3810-193 Aveiro

Geochemistry and Pollution

Jordi Girona 18-26, 08034 Barcelona

Laboratory of Environmental Institute

Okružná 784/42, 97241 Koš

The Department of Objectification of Living Conditions Factors

Cesta k nemocnici 1, Banská Bystrica, 975 56

Banská Bystrica