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News

Nikiforos Alygizakis

Meet the Chemical Leaders - Nikiforos Alygizakis

Nikiforos Alygizakis, researcher at the National and Kapodistrian University of Athens, has dedicated his career to detecting and understanding contaminants of emerging concern. Using advanced mass spectrometry and non-target screening, he has led large-scale monitoring campaigns across Europe, helping to reveal the hidden complexity of chemical mixtures in our environment...

Susana Loureiro

Meet the Chemical Leaders - Susana Loureiro

Susana Loureiro, professor at the University of Aveiro, has built her career at the intersection of ecotoxicology and environmental innovation. Fascinated by how chemicals interact with living organisms and ecosystems, she has become one of Europe’s leading voices on the opportunities and risks of nanomaterials. These materials, celebrated for their...

New innovative methods to identify chemical risk drivers in wastewater

PARC researchers have unveiled a groundbreaking high-throughput method for identifying chemical risk drivers in wastewater, offering significant advancements in both human health surveillance and environmental exposure assessment. The development and use of effect-directed analysis (EDA) for the identification of risk drivers is a key requirement for monitoring, assessment and mitigation...

PARC welcomes the establishment of the new global panel on chemicals, waste and and pollution

The Intergovernmental Science-Policy Panel on Chemicals, Waste and Pollution (ISPCWP) was adopted at an intergovernmental meeting in Punta del Este, Uruguay, in June. After five days of intense negotiations, countries reached an agreement, concluding a three-year debate led by the Open-Ended Working Group (OEWG) established under the United Nations Environment...

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Events

Safe and Sustainable by Design Workshop 2025

The Safe and Sustainable by Design Workshop 2025 (SSbD25), will bring together researchers, policymakers, and industry stakeholders to exchange knowledge and best practices on implementing the European Commission’s SSbD Framework. The workshop aims to strengthen collaboration across disciplines, support the practical application of the SSbD principles, and identify strategies to...

The 45th International Symposium on Halogenated Persistent Organic Pollutants

The annual symposium DIOXIN 2025 focuses on persistent organic pollutants (POPs) including dioxins, furans, flame-retardants, and other halogenated compounds of environmental and health relevance. The programme spans analytical developments, toxicology, risk assessment, regulatory frameworks, environmental monitoring, and remediation. Designed for researchers, regulators, industry and environmental professionals, the event offers a...

Weight of Evidence and Systematic Review Methodology in Health Risk Assessment of Chemicals

The Training Course on Weight of Evidence and Systematic Review Methodology in Health Risk Assessment of Chemicals will be held online from 2 to 6 March 2026. Organised by the Advanced International Training Programme in Health Risk Assessment at the Institute of Environmental Medicine (IMM), Karolinska Institutet, the course offers...

Exposure Science: Tackling Today’s Environmental, Health Challenges and Policy Needs

The ISES Europe Workshop 2025, organized by the International Society of Exposure Science (ISES), will bring together leading scientists, policymakers, and practitioners to discuss how exposure science can address pressing environmental and health challenges. This year’s theme highlights the essential role of exposure assessment in shaping effective environmental and public...

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Projects

Benchmarking the environmental risk assessment of plant protection products

Key messages Consistent risk assessment requires that risks of compounds can be compared and ranked Evaluation of current approach and development of concepts and methodologies to improve comparability Risk assessment outcomes should also hold against relative risks of compounds identified in real world studies Overview This project aims to demonstrate...

Developing a sustainable European human biomonitoring framework

Overview Developing a long-term, sustainable and inclusive human biomonitoring (HBM) framework for assessing chemical exposure across Europe is the main objective of this project. It is building upon previous initiatives, including the HBM4EU aligned studies and the PARC aligned studies, while integrating insights from global experts in Europe, the USA...

Enhancing chemical mixture risk assessment and regulation

Overview This project focuses on current methods for managing chemical mixtures in various regulatory areas, such as REACH, Classification, Labelling and Packaging ( CLP), pesticides, biocides, cosmetics, food contact materials, pharmaceuticals, and regulations concerning food, drinking water, and environmental emissions. Another objective is to evaluate the use of the Mixture...

Advancing the characterisation of human chemical exposome with innovative methods

Key messages Sixty-seven institutions are collaborating under the PARC initiative to enhance the utility of innovative analytical methods and tools for monitoring and surveys, supporting next-generation chemical risk assessment. A network of harmonised laboratories operating standardised innovative methods for chemical exposure characterisation should be established for use as a tool...

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Publications

Occupational exposure limits for reproductive toxicants – A comparative analysis

Occupational exposure limits for reproductive toxicants – A comparative analysis

We investigated the level of protection of reproductive and developmental toxicity offered through occupational exposure limits (OELs) and Derived No-Effect Levels for workers’ inhalation exposure (wDNELs). We compared coverage of substances that have a harmonised classification as reproductive toxicant 1 A or 1B (Repr.1 A/B), numerical values and scientific basis of 12...

Adverse outcomes of the newly emerging bisphenol A substitutes

Adverse outcomes of the newly emerging bisphenol A substitutes

BPA and its analogues are facing increasingly stringent regulations restricting their use due to the increasing knowledge of their harmful effects. It is therefore expected that novel BPA analogues and alternatives will replace them in plastic products, cans and thermal paper to circumvent restrictions imposed by legislation. This raises concerns...

A short-term exposure to saxitoxin triggers a multitude of deleterious effects in Daphnia magna at levels deemed safe for human health

A short-term exposure to saxitoxin triggers a multitude of deleterious effects in Daphnia magna at levels deemed safe for human health

Harmful algal blooms and the toxins produced during these events are a human and environmental health concern worldwide. Saxitoxin and its derivatives are potent natural aquatic neurotoxins produced by certain freshwater cyanobacteria and marine algae species during these bloom events. Saxitoxins effects on human health are well studied, however its...

A systematic workflow for compliancetesting of emerging international classwide restrictions on PFAS

A systematic workflow for compliancetesting of emerging international classwide restrictions on PFAS

The poorly reversible risks to human health and ecosystems from contamination with per- and polyfluoroalkyl substances (PFAS) have led many researchers and regulators worldwide to call for a classwide ban of these so-called forever chemicals. As part of the EU Chemicals Strategy for Sustainability, the national authorities of five European...

78 results

Deliverables

PARCroute roadmap 1

Database and roadmap for SYNnet

Communication and Dissemination Strategy

Annual Work Plan (AWP) Y2 including PARC Project Portfolio

99 results

Learning materials

Information map ‘Safe and Sustainable by Design’ of chemicals and materials

This information map provides an overview of "Safe and Sustainable by Design" (SSbD) for companies developing chemicals and materials. Based on expert input, it includes guidance on SSbD principles and practical tips to help businesses integrate sustainability into their operations.

NanoCommons User Guidance | Safe-and-Sustainable-by-Design

This handbook provides a comprehensive guide to nanosafety, with sections on data management, nanoinformatics, and emerging topics. Included is a detailed subsection on Safe-and-Sustainable-by-Design (SSbD), addressing the framework for safety and sustainability in material innovation.

Training practices on nanomaterials and advanced materials for workers safety and health: stakeholders consultation report

Focused on occupational safety, this report explores training needs for workers handling nanomaterials and advanced materials. It includes insights from stakeholder consultations and outlines guidelines for harmonized risk management training across Europe.

2nd Safe and Sustainable by Design stakeholder workshop

Explore the EU Commission's proposed framework for Safe and Sustainable by Design (SSbD). This workshop discusses its stepwise process, assessment methods, and key aspects of implementation. Case studies and next steps in the criteria’s development are also explored.

203 results

Partners

Environment Agency

Horizon House, Deanery Road, BS1 5AH

Nantes-Atlantic National College of Veterinary Medicine, Food Science and Engineering

101 Rte de Gachet, 44300

University for Veterinary Medicine Hannover

Bünteweg 2, 30559 Hannover

Mario Negri Institute for Pharmacological Research

Via Mario Negri, 2, 20156 MI

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Laboratories

University of Applied Sciences and Arts Northwestern Switzerland (FHNW)

FHNW, Hofackerstrasse 30, 4232 Muttenz, Switzerland

Masaryk University

Kamenice 753, 625 00 Brno-Bohunice

National Research Institute for Agriculture, Food and the Environment (INRAE)

5 rue de la Doua - CS 20244, 69625 Villeurbanne Cedex

National Research Institute for Agriculture, Food and the Environment (INRAE)

180 chemin de Tournefeuille - BP. 93173; F-31027 TOULOUSE cedex 3