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News

Training - 2nd in silico models and read-across

PARC online training: exercises with in silico models and read-across using VEGAHUB

PARC is organising a second remote training course on in silico models and read-across, this time focusing on hands-on interpretation and practical application using the VEGAHUB platform. The training will take place on 23-24 October 2025, with morning or afternoon sessions depending on participant numbers. The course is coordinated by...

Nikiforos Alygizakis

Meet the Chemical Leaders - Nikiforos Alygizakis

Nikiforos Alygizakis, researcher at the National and Kapodistrian University of Athens, has dedicated his career to detecting and understanding contaminants of emerging concern. Using advanced mass spectrometry and non-target screening, he has led large-scale monitoring campaigns across Europe, helping to reveal the hidden complexity of chemical mixtures in our environment...

Susana Loureiro

Meet the Chemical Leaders - Susana Loureiro

Susana Loureiro, professor at the University of Aveiro, has built her career at the intersection of ecotoxicology and environmental innovation. Fascinated by how chemicals interact with living organisms and ecosystems, she has become one of Europe’s leading voices on the opportunities and risks of nanomaterials. These materials, celebrated for their...

New innovative methods to identify chemical risk drivers in wastewater

PARC researchers have unveiled a groundbreaking high-throughput method for identifying chemical risk drivers in wastewater, offering significant advancements in both human health surveillance and environmental exposure assessment. The development and use of effect-directed analysis (EDA) for the identification of risk drivers is a key requirement for monitoring, assessment and mitigation...

237 results

Events

Introduction to Statistics and Data Visualisation with R

The Introduction to Statistics and Data Visualisation with R course will be held from 26 to 29 January 2026 at the University of Lausanne, Switzerland. This four-day, in-person training is designed to provide researchers in the biomedical sciences with hands-on experience in applying core statistical techniques using the R programming...

Using Omics Bioactivity Data to Increase Confidence in Chemical Groups

The webinar on Using Omics Bioactivity Data to Increase Confidence in Chemical Groups, organised by PrecisionTox, took place online on 10 December 2025. The session examined how omics bioactivity data can enhance confidence in chemical grouping and presented perspectives from both regulatory authorities and industry, highlighting the role of grouping...

Pesticides & Organic Micropollutants Conference 2025

The European Conference on Pesticides and related Organic Micropollutants in the Environment 2025 (PESTIPOLL 2025) will convene experts from environmental chemistry, analytical science, regulatory policy and academia to address the detection, behaviour and risk assessment of pesticides and organic micropollutants. The event explores advanced instrumentation, data integration and monitoring across...

Fourth SYNnet Workshop on Synergies with External Initiatives

SYNnet is pleased to invite you to the 4 th Workshop on Synergies with External Initiatives, which will be held virtually on 19 November 2025, from 10:00 to 12:30 CET. Join us to explore opportunities for collaboration between PARC and key initiatives from the ExpoHealthNet Cluster. The link for online...

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Projects

Advancing the characterisation of human chemical exposome with innovative methods

Key messages Sixty-seven institutions are collaborating under the PARC initiative to enhance the utility of innovative analytical methods and tools for monitoring and surveys, supporting next-generation chemical risk assessment. A network of harmonised laboratories operating standardised innovative methods for chemical exposure characterisation should be established for use as a tool...

Benchmarking the environmental risk assessment of plant protection products

Key messages Consistent risk assessment requires that risks of compounds can be compared and ranked Evaluation of current approach and development of concepts and methodologies to improve comparability Risk assessment outcomes should also hold against relative risks of compounds identified in real world studies Overview This project aims to demonstrate...

Implementing human biomonitoring as sentinel surveillance system

Key messages The study identifies occupational exposure pathways and their health impacts, providing a foundation for evidence-based regulations to protect workers and reduce occupational health risks. Sentinel surveillance delivers early warnings on emerging health threats, enabling timely preventive actions and enhancing EU health resilience. The findings support targeted strategies to...

Improving the environmental risk assessment for plant protection products

Key messages Reach a common understanding of what needs to be improved in the environmental risk assessment for plant protection products, such as the need to: Overcome the limitations of the current substance-by-substance approach, Adopt a more realistic consideration of the environmental context. Address issues related to improving environmental risk...

175 results

Publications

A conceptual framework for landscape-based environmental risk assessment (ERA) of pesticides

A conceptual framework for landscape-based environmental risk assessment (ERA) of pesticides

While pesticide use is subject to strict regulatory oversight worldwide, it remains a main concern for environmental protection, including biodiversity conservation. This is partly due to the current regulatory approach that relies on separate assessments for each single pesticide, crop use, and non-target organism group at local scales. Such assessments...

Occupational exposure limits for reproductive toxicants – A comparative analysis

Occupational exposure limits for reproductive toxicants – A comparative analysis

We investigated the level of protection of reproductive and developmental toxicity offered through occupational exposure limits (OELs) and Derived No-Effect Levels for workers’ inhalation exposure (wDNELs). We compared coverage of substances that have a harmonised classification as reproductive toxicant 1 A or 1B (Repr.1 A/B), numerical values and scientific basis of 12...

Adverse outcomes of the newly emerging bisphenol A substitutes

Adverse outcomes of the newly emerging bisphenol A substitutes

BPA and its analogues are facing increasingly stringent regulations restricting their use due to the increasing knowledge of their harmful effects. It is therefore expected that novel BPA analogues and alternatives will replace them in plastic products, cans and thermal paper to circumvent restrictions imposed by legislation. This raises concerns...

A short-term exposure to saxitoxin triggers a multitude of deleterious effects in Daphnia magna at levels deemed safe for human health

A short-term exposure to saxitoxin triggers a multitude of deleterious effects in Daphnia magna at levels deemed safe for human health

Harmful algal blooms and the toxins produced during these events are a human and environmental health concern worldwide. Saxitoxin and its derivatives are potent natural aquatic neurotoxins produced by certain freshwater cyanobacteria and marine algae species during these bloom events. Saxitoxins effects on human health are well studied, however its...

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Deliverables

Inventory of existing EBD, HIA, exposure and exposure-effect data for chemicals prioritized in PARC

Development of the strategy for mixture risk assessment using HBM data and its application to prioritised mixtures

Inventory of PBK models for assessing the internal exposure through life

Roadmap on aggregated exposure strategy through different sources and routes related to general and occupational environments

102 results

Learning materials

This video introduces the concept of Safe-by-Design (SbD) and explores its importance in integrating safety into innovation workflows. Learn how SbD anticipates risks in emerging technologies and helps develop sustainable, responsible, and safe innovations.

Nanosafety | NanoLund

Discover insights into nanomaterials' human and environmental toxicology, as well as of emissions and exposure in all stages of the lifecycle of a nanomaterial. This research supports Safe(r)-and-sustainable-by-design approaches in developing and producing novel materials.

Safe Innovation Approach (SIA)

Introduces the Safe Innovation Approach, combining Safe by Design and Regulatory Preparedness to address safety early in the innovation process, with a focus on nanomaterials.

PLANETS 1st SSbD Training on Scoping

Covers SSbD policy context, scoping actions, and a case-based walkthrough of the PLANETS Workflow, with full supporting materials and worksheet.

203 results

Partners

Austrian Institute of Technology GmbH

Giefinggasse 4, 1210 Wien

University Medical Centre Maribor

Ljubljanska ulica 5, 2000

University of Gratz

Universitätspl. 3, 8010

Foundation for the Promotion of Health and Biomedical Research of Valencia Region

Av. de Catalunya, 21, 46020 València

251 results

Laboratories

University of Aveiro

Building 3, 5th floor, Santiago University Campus, University of Aveiro, 3810-193 Aveiro

University of South Bohemia in České Budějovice

Zátiší 728/II, 389 25 Vodňany

University of Applied Sciences and Arts Northwestern Switzerland (FHNW)

FHNW, Hofackerstrasse 30, 4232 Muttenz, Switzerland

Masaryk University

Kamenice 753, 625 00 Brno-Bohunice