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News

PBK models - kids

An inventory of physiologically based kinetic models for assessing lifetime internal exposure is now available

A new inventory from PARC provides an overview of the physiologically based kinetic (PBK) models assessing the internal exposure in humans during life concerning five groups of chemicals: bisphenols, metals, mycotoxins, perfluorinated compounds, and pesticides. Twenty-one European institutes from ten countries have joined forces, under PARC, to develop a strategy...

human exposure to chemicals

Building the road for assessing aggregate human exposure to chemicals, covering different sources, routes and environments

Thirty-six European institutes from sixteen countries joined forces, under PARC, to propose a more integrative risk assessment and risk management of the human aggregate exposure to chemicals. The work includes development of methods, tools and results to advance knowledge on the combination of the different chemicals’ sources and the different...

PARC Junior Community

PARC Junior Community is looking for new members

Are you a student, recent graduates and early career researchers involved in PARC activities? Then keep reading! Nearing the end of 2023, the PARC Coordination Team envisioned the start of a community tailored for students, recent graduates up to five years after the completion of their degree and early career...

Tribute to Gudrun Koppen

With deep grief we let you know that our good colleague and dear friend Gudrun Koppen passed away on 31 January 2024. Very courageous and keeping a positive spirit, she finally lost an unfair batle against cancer. Gudrun was born on 23 January 1969. She graduated as an Engineer in...

237 results

Events

Global Impacts of Biotoxins on the Safety and Sustainability of Food and Water

The Gordon Research Conference on Mycotoxins and Phycotoxins is an esteemed international event focusing on the latest advances in biotoxin research. This conference brings together academic, government, and private sector scientists to explore topics such as human and ecosystem health, analytical methods, modelling, mitigation, and the biology and ecology of...

In silico models and read-across

PARC organised a remote training course on In Silico Models and Read-Across, which took place from 3 to 4 March 2025 under the scientific coordination of the Istituto di Ricerche Farmacologiche Mario Negri (IRFMN), Italy. The program introduced participants to the principles, applications, and limitations of in silico models, with...

Postgraduate course on Human Exposure Assessment (3rd Edition)

The 3rd edition of the Postgraduate Course on Human Exposure Assessment took place in Nijmegen, the Netherlands, from 13 to 15 May 2025 on-site and continued online from 26 to 27 May 2025. The program focused on exposure as an integral and necessary component in the chain of events leading...

13th BfR-Summer Academy on Risk Assessment and Risk Communication

Short overview The 13th BfR-Summer Academy on Risk Assessment and Risk Communication in Food Safety combines theoretical background with interactive workshops to build participant competencies in food safety, focusing on hazard and exposure assessment, risk communication, data quality, and uncertainty analysis, with an emphasis on European frameworks. Target audience Staff...

175 results

Publications

The exposure of Czech firefighters to perfluoroalkyl substances and polycyclic aromatic hydrocarbons: CELSPAC – FIREexpo case-control human biomonitoring study

The exposure of Czech firefighters to perfluoroalkyl substances and polycyclic aromatic hydrocarbons: CELSPAC – FIREexpo case-control human biomonitoring study

The CELSPAC - FIREexpo biomonitoring study investigates the long-term effects of chemical exposure on firefighters' wellness and fitness. It aims to provide science-based measures to minimize the health risks of the firefighting occupation. Here, we present the study design, cohort profile, and first results with respect to internal per- and...

Modernizing persistence–bioaccumulation–toxicity (PBT) assessment with high throughput animal‑free methods

The assessment of persistence (P), bioaccumulation (B), and toxicity (T) of a chemical is a crucial first step at ensuring chemical safety and is a cornerstone of the European Union’s chemicals regulation REACH (Registration, Evaluation, Authorization, and Restriction of Chemicals). Existing methods for PBT assessment are overly complex and cumbersome...

Carnosic acid ameliorates indomethacin-induced gastric ulceration in rats by alleviating oxidative stress and inflammation

Carnosic acid ameliorates indomethacin-induced gastric ulceration in rats by alleviating oxidative stress and inflammation

Nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin and indomethacin (IND) are the most commonly prescribed for inflammation or pain. However, widespread use causes several adverse effects, such as gastric ulcers, upper gastric system bleeding, and erosions. Carnosic acid (CA) is an important natural antioxidant found in rosemary (Rosmarinus essentials) and...

Cover_development

Development of historic monthly land use regression models of SO2, NOx and suspended particulate matter for birth cohort ELSPAC

Vulnerable windows in child development in utero and after birth are critical time points for uncovering the links between environment and health. Particular attention is paid to the first 1000 days of life from conception to the second year of life. The ELSPAC (European Longitudinal Study of Pregnancy and Childhood)...

203 results

Partners

National Public Health Surveillance Laboratory

Žolyno g. 36, 10210

Norwegian Institute for Air Research

Instituttveien 18, 2007

University of Aveiro

Universidade de , 3810-193

Medical University of Vienna

Spitalgasse 23, 1090 Wien

251 results

Laboratories

Department of Environmental and Resource Engineering, Indoor Climate Section

Nils Koppels Alle 402

Group for Chemical Work Environment

Gydas vei 8, 0363, Oslo

Italian National Reference Laboratory/Department of Foof Safety, Nutrition and Vet Public Health

Viale Regina Elena 299, 00161 Rome

Institute of Legal Medicine and Core Facility Metabolomics

Muellerstrasse, 44, 6020, Innsbruck