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News

share views ngra

PARC invites all to share views on roadmap towards NGRA

Have your say and join PARC and the European Commission in paving the way for Next-Generation Chemical Risk Assessment (NGRA). PARC invites all to share comments, ideas, and suggestions regarding guiding principles for an NGRA framework and tentative work streams for a roadmap to establish NGRA in EU chemicals legislation...

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PARC supports education of postgraduates and young professionals

Postgraduates and young professionals can already by now mark in their calendar that by July 2024 they will have free of charge access to the 10 th Summer School on Sustainable Chemistry for Sustainable Development at Leuphana University in Lüneburg, Germany. Focus will be on sustainable chemistry and Safe-and-Sustainable-by-Design (SSbD)...

PARC launches new community platform for chemical risk assessment professionals

The Partnership for the Assessment of Risk from Chemicals has launched PARCopedia, a new online knowledge base and community platform for people involved in chemical risk assessment. The new PARCopedia platform supports knowledge sharing among professionals with the goal of innovating chemical risk assessment methodology towards Next-Generation Risk Assessment (NGRA)...

Workshop on phasing out animal testing

On 11 and 12 December 2023 a workshop with PARC participation will take place in Brussels and online. The workshop title is "A roadmap for phasing out animal testing in chemical safety assessments". During the workshop speakers from the European Commission, the EU regulatory agencies EFSA, ECHA and EMA, NGOs...

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Events

Seminar: Towards next generation assessment and identification of endocrine disruptors

On 12 December 2024, a hybrid-format seminar will be held in Solna, Sweden, hosted by the Karolinska Institutet. The event will spotlight innovative methods for identifying hormone-disrupting substances, aiming to foster dialogue and showcase cutting-edge research in the field of endocrine disruption. Lucia Vergauwen from the University of Antwerp will...

PARC at the 35th Annual Meeting of the Society of Environmental Toxicology and Chemistry

The 35 th Annual Meeting of the Society of Environmental Toxicology and Chemistry (SETAC Europe) will be held in Vienna, Austria (11-15 May 2025), bringing together leading experts to advance environmental science and promote science-informed decision-making through collaboration and education. Several PARC partners will present research focused on a range...

64th Annual Meeting and ToxExpo of the Society of Toxicology

Experience the forefront of toxicology innovation at the 64 th Annual Meeting and ToxExpo of the Society of Toxicology, taking place from March 16–20, 2025, in Orlando, Florida, USA. This renowned event unites leading toxicologists and industry experts to explore the latest advancements in science and technology, fostering collaboration and...

Webinar on Machine learning methods applied to toxicology with biological data - Examples with transcriptomics and cell morphology read out

The Eurotox Faculty Programme hosted a complimentary online webinar on Machine Learning Methods Applied to Toxicology with Biological Data – Examples with Transcriptomics and Cell Morphology Read Out on 12 December 2024. The session was led by Dr. Olivier Taboureau from Université Paris Cité, France, and introduced participants to the...

166 results

Publications

Cover_A walk in the PARC: developing and implementing 21st century chemical risk assessment in Europe

A walk in the PARC: Developing and implementing 21st century chemical risk assessment in Europe

Current approaches for the assessment of environmental and human health risks due to exposure to chemical substances have served their purpose reasonably well. Nevertheless, the systems in place for different uses of chemicals are faced with various challenges, ranging from a growing number of chemicals to changes in the types...

Cover_Application of AOPs to assist regulatory assessment of chemical risks – Case studies, needs and recommendations

Application of AOPs to assist regulatory assessment of chemical risks – Case studies, needs and recommendations

While human regulatory risk assessment (RA) still largely relies on animal studies, new approach methodologies (NAMs) based on in vitro, in silico or non-mammalian alternative models are increasingly used to evaluate chemical hazards. Moreover, human epidemiological studies with biomarkers of effect (BoE) also play an invaluable role in identifying health...

Dynamic metabolic and transcriptional responses of proteasome-inhibited neurons

Dynamic metabolic and transcriptional responses of proteasome-inhibited neurons

Proteasome inhibition is associated with parkinsonian pathology in vivo and degeneration of dopaminergic neurons in vitro. We explored here the metabolome (386 metabolites) and transcriptome (3257 transcripts) regulations of human LUHMES neurons, following exposure to MG-132 [100 nM]. This proteasome inhibitor killed cells within 24 h but did not reduce...

Adverse (geno)toxic effects of bisphenol A and its analogues in hepatic 3D cell model

Adverse (geno)toxic effects of bisphenol A and its analogues in hepatic 3D cell model

Bisphenol A (BPA) is one of the most widely used and versatile chemical compounds in polymer additives and epoxy resins for manufacturing a range of products for human applications. It is known as endocrine disruptor, however, there is growing evidence that it is genotoxic. Because of its adverse effects, the...

203 results

Partners

Institut "Jožef Stefan"

Jamova cesta 39, 1000

Catholic University of Leuven

Oude Markt 13, 3000

National Institute for Occupational Safety and Health

Torrelaguna 73, 28027

Institute of Health Information and Statistics of the Czech Republic

Palackého nám. 375, 128 00 Nové Město

251 results

Laboratories

Zero Pollution & Labor, Team Organic Analysis, Team Inorganic Analysis, Spectroscopy & GMO, Team Pollutants

Spittelauer Länder 5, 1090 Wien

Platform for chromatography and mass spectrometry

Juliette Wytsmanstraat 14, 1050 Brussels

Laboratory of Organic Analysis and References; Chemistry Department

Department of Environment and Health

Viale Regina Elena 299, 00161 Rome