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News

PARC inspired ECHA’s scientific research needs

Which research areas should be prioritised to lead the way for future regulation of hazardous chemicals? In a recent report the European Chemicals Agency (ECHA) gives its advice inspired by PARC. The report ‘ Key areas of regulatory challenge 2023’ identifies areas where research is needed to protect people and...

share views ngra

PARC invites all to share views on roadmap towards NGRA

Have your say and join PARC and the European Commission in paving the way for Next-Generation Chemical Risk Assessment (NGRA). PARC invites all to share comments, ideas, and suggestions regarding guiding principles for an NGRA framework and tentative work streams for a roadmap to establish NGRA in EU chemicals legislation...

Young professionals looking at a computer

PARC supports education of postgraduates and young professionals

Postgraduates and young professionals can already by now mark in their calendar that by July 2024 they will have free of charge access to the 10 th Summer School on Sustainable Chemistry for Sustainable Development at Leuphana University in Lüneburg, Germany. Focus will be on sustainable chemistry and Safe-and-Sustainable-by-Design (SSbD)...

PARC launches new community platform for chemical risk assessment professionals

The Partnership for the Assessment of Risk from Chemicals has launched PARCopedia, a new online knowledge base and community platform for people involved in chemical risk assessment. The new PARCopedia platform supports knowledge sharing among professionals with the goal of innovating chemical risk assessment methodology towards Next-Generation Risk Assessment (NGRA)...

237 results

Events

Webinar: Insights from PARC Report on Screening and Enforcement Structures

This webinar will present findings from the PARC Report on Current Screening and Enforcement Structures. The report examines enforcement practices and challenges across the EU, focusing on chemicals in articles, complex objects, and chemical products under key regulations such as REACH (Registration, Evaluation, Authorization and Restriction of Chemicals), POP (Persistent...

Innovative Risk Assessment Methodologies – PARC case studies Webinar

Join us for a dedicated webinar for Governing Board, International Board, and Stakeholder Forum members, featuring insights from two case studies from PARC Work Package 6: Innovation in Regulatory Risk Assessment, under Task 6.3: Review of risk assessment methodologies, on: Identification of loopholes for substances with biocidal properties; Methods to...

PARC Workshop: Join the PARC Ethics Webinar

The PARC co-leaders of the Task on “Ethics & Data Protection Politics”, Lucija Perharic and Philippe Marin, with support from the Data and Ethics Protection Board and the Work Package on “Building infrastructural and human capacities”, invite you to a dedicated online ethics webinar on Thursday, December 12, 2024, from...

175 results

Publications

Cover_Metabolism-Disrupting Chemicals Affecting the Liver: Screening, Testing, and Molecular Pathway Identification

Metabolism-disrupting chemicals affecting the liver: Screening, testing, and molecular pathway identification

The liver is the central metabolic organ of the body. The plethora of anabolic and catabolic pathways in the liver is tightly regulated by physiological signaling but may become imbalanced as a consequence of malnutrition or exposure to certain chemicals, so-called metabolic endocrine disrupters, or metabolism-disrupting chemicals (MDCs). Among different...

Cover_A walk in the PARC: developing and implementing 21st century chemical risk assessment in Europe

A walk in the PARC: Developing and implementing 21st century chemical risk assessment in Europe

Current approaches for the assessment of environmental and human health risks due to exposure to chemical substances have served their purpose reasonably well. Nevertheless, the systems in place for different uses of chemicals are faced with various challenges, ranging from a growing number of chemicals to changes in the types...

Cover_Application of AOPs to assist regulatory assessment of chemical risks – Case studies, needs and recommendations

Application of AOPs to assist regulatory assessment of chemical risks – Case studies, needs and recommendations

While human regulatory risk assessment (RA) still largely relies on animal studies, new approach methodologies (NAMs) based on in vitro, in silico or non-mammalian alternative models are increasingly used to evaluate chemical hazards. Moreover, human epidemiological studies with biomarkers of effect (BoE) also play an invaluable role in identifying health...

Dynamic metabolic and transcriptional responses of proteasome-inhibited neurons

Dynamic metabolic and transcriptional responses of proteasome-inhibited neurons

Proteasome inhibition is associated with parkinsonian pathology in vivo and degeneration of dopaminergic neurons in vitro. We explored here the metabolome (386 metabolites) and transcriptome (3257 transcripts) regulations of human LUHMES neurons, following exposure to MG-132 [100 nM]. This proteasome inhibitor killed cells within 24 h but did not reduce...

203 results

Partners

Croatian Institute of Public Health

Rockeffelerova 7, 10 000

RISE Reserch Institutes of Sweden

Drottning Kristinas väg 61, 114 28

Ministry of Social Affairs

Suur-Ameerika 1, 10129

Università della Svizzera Italiana

Via Buffi 13, 6900

251 results

Laboratories

Toxicology Service; University Institute of Biomedical and Sanitary Research

Paseo Blas Cabrera "Físico" s/n, 35016 - Las Palmas de Gran Canaria

Las Palmas de Gran Canaria

Instrumental Analysis

1649-003 Lisboa

Department of Food Safety

Lovisenberggata 8, 0456 Oslo

Laboratory Medicine - Occupational and Environmental Medicine

Scheelevägen 8, 223 81 Lund